The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination.
The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination.
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DOI：
10.1038/s41598-021-89206-3
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发表时间：
2021-05-07
影响因子：
4.6
通讯作者：
Rose M
中科院分区：
文献类型：
--
作者：
Taesler P;Rose M
疼痛的体验是通过激活整个复杂的疼痛网络而产生的，岛叶皮质是一个中央处理区。正在进行的振荡活动的状态可能会影响整个网络中的后续处理。特别是，正在进行的theta-band功率可能与后来的疼痛处理相关，但与刺激后处理或行为的直接功能关系缺失。在这里，我们使用了一个非侵入性的脑机接口来增加或减少源自岛叶皮质的持续的theta-band功率。我们的结果显示了振荡功率的差动调制，更重要的是转移到独立测量的疼痛处理和感觉上。痛觉诱发的神经功能和主观痛觉辨别力受到振荡状态诱导调制的不同影响。这些结果证明了基于岛区的theta-band振荡状态与伤害性刺激的加工和主观辨别具有功能相关性，并为临床应用提供了前景。
The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be relevant for later pain processing, however a direct functional relation to post-stimulus processing or behaviour is missing. Here, we used a non-invasive brain–computer interface to either increase or decrease ongoing theta-band power originating in the insular cortex. Our results show a differential modulation of oscillatory power and even more important a transfer to independently measured pain processing and sensation. Pain evoked neural power and subjective pain discrimination were differentially affected by the induced modulations of the oscillatory state. The results demonstrate a functional relevance of insular based theta-band oscillatory states for the processing and subjective discrimination of nociceptive stimuli and offer the perspective for clinical applications.
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影响因子：
5.7
作者：
Cauda F;Costa T;Torta DM;Sacco K;D'Agata F;Duca S;Geminiani G;Fox PT;Vercelli A
通讯作者：
Vercelli A
DOI：
10.1073/pnas.0505210102
发表时间：
2005-12-20
影响因子：
11.1
作者：
deCharms, RC;Maeda, F;Mackey, SC
通讯作者：
Mackey, SC
影响因子：
5.7
作者：
Kelly, Clare;Toro, Roberto;Di Martino, Adriana;Cox, Christine L.;Bellec, Pierre;Castellanos, F. Xavier;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
--
作者：
Oostenveld R;Fries P;Maris E;Schoffelen JM
通讯作者：
Schoffelen JM
影响因子：
3
作者：
Emmert K;Breimhorst M;Bauermann T;Birklein F;Van De Ville D;Haller S
通讯作者：
Haller S