Comparison of anterior cingulate vs. insular cortex as targets for real-time fMRI regulation during pain stimulation.
Comparison of anterior cingulate vs. insular cortex as targets for real-time fMRI regulation during pain stimulation.
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DOI：
10.3389/fnbeh.2014.00350
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发表时间：
2014
影响因子：
3
通讯作者：
Haller S
中科院分区：
文献类型：
--
作者：
Emmert K;Breimhorst M;Bauermann T;Birklein F;Van De Ville D;Haller S
实时功能磁共振成像（rt-fMRI）神经反馈允许通过操作性条件反射来学习对特定大脑区域的自主控制，并已被证明可以减少疼痛感知。为了进一步增加rt-fMRI神经反馈对疼痛的影响，我们直接比较了疼痛网络的两个不同目标区域，特别是前岛皮层（AIC）和前扣带皮层（ACC）。这项前瞻性研究的参与者被随机分配到两个年龄匹配的组，每组14人（每组7名女性）进行AIC和ACC反馈。首先，使用块设计热痛刺激进行功能定位，以确定AIC或ACC内的疼痛敏感靶区。其次，在相同的疼痛刺激过程中，受试者被要求在四次神经反馈运行中下调BOLD的激活。数据分析包括任务相关和功能连接分析。在行为水平上，反馈组和定位组的疼痛评分显著降低，但AIC组和ACC组之间没有差异。在神经影像学方面，在任务相关分析和功能连接分析中，ACC和AIC显示学习下调的受试者的尾状核一致参与（17/28）。前扣带与尾状核的功能连接更强，而前扣带与腹外侧前额皮质的功能连接更强。因此，前扣带和前扣带是疼痛感知过程中实时fMRI神经反馈的合适目标，因为它们都影响尾状核，尽管功能连接表明前扣带的直接连接似乎更强。此外，尾状核是参与疼痛感知和抑制的重要区域，它本身可能是一个很好的rt-fMRI目标。未来的研究需要确定成功调节的参数，并评估重复的rt-fMRI神经反馈对疼痛感知的影响。
Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback allows learning voluntary control over specific brain areas by means of operant conditioning and has been shown to decrease pain perception. To further increase the effect of rt-fMRI neurofeedback on pain, we directly compared two different target regions of the pain network, notably the anterior insular cortex (AIC) and the anterior cingulate cortex (ACC). Participants for this prospective study were randomly assigned to two age-matched groups of 14 participants each (7 females per group) for AIC and ACC feedback. First, a functional localizer using block-design heat pain stimulation was performed to define the pain-sensitive target region within the AIC or ACC. Second, subjects were asked to down-regulate the BOLD activation in four neurofeedback runs during identical pain stimulation. Data analysis included task-related and functional connectivity analysis. At the behavioral level, pain ratings significantly decreased during feedback vs. localizer runs, but there was no difference between AIC and ACC groups. Concerning neuroimaging, ACC and AIC showed consistent involvement of the caudate nucleus for subjects that learned down-regulation (17/28) in both task-related and functional connectivity analysis. The functional connectivity toward the caudate nucleus is stronger for the ACC while the AIC is more heavily connected to the ventrolateral prefrontal cortex. Consequently, the ACC and AIC are suitable targets for real-time fMRI neurofeedback during pain perception as they both affect the caudate nucleus, although functional connectivity indicates that the direct connection seems to be stronger with the ACC. Additionally, the caudate, an important area involved in pain perception and suppression, could be a good rt-fMRI target itself. Future studies are needed to identify parameters characterizing successful regulators and to assess the effect of repeated rt-fMRI neurofeedback on pain perception.
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影响因子：
3.3
作者：
Drdla, Ruth;Sandkuehler, Juergen
通讯作者：
Sandkuehler, Juergen
影响因子：
5.7
作者：
Cauda F;Costa T;Torta DM;Sacco K;D'Agata F;Duca S;Geminiani G;Fox PT;Vercelli A
通讯作者：
Vercelli A
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
DOI：
10.1073/pnas.0505210102
发表时间：
2005-12-20
影响因子：
11.1
作者：
deCharms, RC;Maeda, F;Mackey, SC
通讯作者：
Mackey, SC
影响因子：
14.5
作者：
Bantick, SJ;Wise, RG;Tracey, I
通讯作者：
Tracey, I