Activation of Sonic Hedgehog Signaling Promotes Differentiation of Cortical Layer 4 Neurons via Regulation of Their Cell Positioning.
Activation of Sonic Hedgehog Signaling Promotes Differentiation of Cortical Layer 4 Neurons via Regulation of Their Cell Positioning.
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DOI：
10.3390/jdb10040050
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发表时间：
2022-11-25
影响因子：
2.7
通讯作者：
Motoyama, Jun
中科院分区：
文献类型：
--
作者：
Oishi, Koji;Nakajima, Kazunori;Motoyama, Jun
哺乳动物大脑皮层中的神经元亚型在发育过程中由内在和外在机制决定。然而，参与这一过程的外在线索在很大程度上仍然未知。在这里，我们调查的作用，音刺猬（嘘）在mammatergic皮质亚型规范。我们发现，E14.5出生的，但不是E15.5出生的，神经元与Shh表达升高经常分化成第4层亚型的细胞定位和分子身份的判断。我们进一步发现，这种效应是通过调节细胞定位间接实现的，而不是直接激活第4层分化程序。总之，我们提供的证据表明，嘘，一个外在的因素，发挥了重要的作用，在规范的皮质浅层亚型。
Neuronal subtypes in the mammalian cerebral cortex are determined by both intrinsic and extrinsic mechanisms during development. However, the extrinsic cues that are involved in this process remain largely unknown. Here, we investigated the role of sonic hedgehog (Shh) in glutamatergic cortical subtype specification. We found that E14.5-born, but not E15.5-born, neurons with elevated Shh expression frequently differentiated into layer 4 subtypes as judged by the cell positioning and molecular identity. We further found that this effect was achieved indirectly through the regulation of cell positioning rather than the direct activation of layer 4 differentiation programs. Together, we provided evidence that Shh, an extrinsic factor, plays an important role in the specification of cortical superficial layer subtypes.
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影响因子：
16.2
作者：
Molyneaux, BJ;Arlotta, P;Macklis, JD
通讯作者：
Macklis, JD
DOI：
10.1073/pnas.0509032102
发表时间：
2005-12-06
影响因子：
11.1
作者：
Chen, JG;Rasin, MR;Sestan, N
通讯作者：
Sestan, N
影响因子：
16.2
作者：
Hevner, RF;Shi, LM;Rubenstein, JLR
通讯作者：
Rubenstein, JLR
DOI：
10.1146/annurev-cellbio-100814-125353
发表时间：
2015
影响因子：
11.3
作者：
Lodato S;Arlotta P
通讯作者：
Arlotta P
影响因子：
16.2
作者：
Alcamo, Elizabeth A.;Chirivella, Laura;McConnell, Susan K.
通讯作者：
McConnell, Susan K.