Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo.
Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo.
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黄芪多糖在体外和体内具有增强免疫力和抑制H9N2禽流感病毒的作用。
DOI:
10.1186/2049-1891-4-22
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发表时间:
2013-06-21
影响因子:
7
通讯作者:
Zhang Y
中科院分区:
文献类型:
--
作者:
Kallon S;Li X;Ji J;Chen C;Xi Q;Chang S;Xue C;Ma J;Xie Q;Zhang Y
This study investigated the humoral immunization of Astragalus polysaccharide (APS) against H9N2 avian influenza virus (H9N2 AIV) infection in chickens. The effects of APS treatment on H9N2 infection was evaluated by an MTT [3(4, 5-dimethylthiazol-2-yl)-2, 3-diphenyl tetrazolium bromide] assay and analysis of MHC and cytokine mRNA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to H9N2 AIV were enhanced in the first week after APS treatment. The results indicated that APS treatment reduces H9N2 AIV replication and promotes early humoral immune responses in young chickens.
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影响因子:
5.5
作者:
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通讯作者:
Liu, Jiaguo
DOI:
10.1016/j.ijbiomac.2009.11.011
发表时间:
2010-03-01
影响因子:
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5.4
作者:
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Fu, Su-Zhen