Adjuvant activity of Sargassum pallidum polysaccharides against combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines.

Adjuvant activity of Sargassum pallidum polysaccharides against combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines.
复制标题

DOI:
10.3390/md10122648
复制
发表时间:
2012-12
期刊:
影响因子:
5.4
通讯作者:
Lun Z
Lun Z
中科院分区:
医学2区
文献类型:
--
作者:
Li LJ;Li MY;Li YT;Feng JJ;Hao FQ;Lun Z

文献摘要

参考文献

被引文献

相似文献

本研究探讨了海藻多糖(SPP)对鸡免疫功能的影响。通过检测鸡新城疫(纽卡斯尔病)、传染性支气管炎(IB)和禽流感(AI)免疫后的抗体效价和淋巴细胞增殖反应,研究了海藻多糖对鸡新城疫(ND)、传染性支气管炎(IB)和禽流感(AI)的佐剂作用。分别以含10、30和50 mg/mL SPP的ND、IB和AI三联灭活苗免疫鸡,以油乳剂苗为对照。30 mg/mL SPP可增强ND、IB和AI抗体滴度及淋巴细胞增殖反应。总之,适当剂量的SPP可能是一种安全有效的免疫刺激剂候选物,适用于疫苗产生早期和持久的预防作用。
This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.
DOI: 10.1016/j.ijbiomac.2012.01.002
发表时间: 2012-04-01
影响因子: 8.2
作者:
Guo, Liwei;Wang, Deyun;Gao, Huan
通讯作者: Gao, Huan
硫酸化修饰可增强香菇多糖的佐剂作用,提高ND疫苗的免疫效果
DOI: 10.1016/j.vaccine.2008.11.038
发表时间: 2009-01-29
期刊: VACCINE
影响因子: 5.5
作者:
Guo, Zhenhuan;Hu, Yuanliang;Liu, Ping
通讯作者: Liu, Ping
DOI: 10.1016/j.jneuroim.2005.12.007
发表时间: 2006-04-01
影响因子: 3.3
作者:
Ashwood, P;Wakefield, AJ
通讯作者: Wakefield, AJ
DOI: 10.1016/j.vaccine.2008.11.046
发表时间: 2009-02-05
期刊: VACCINE
影响因子: 5.5
作者:
de Vries, J. J. C.;Bungener, L.;Huckriede, A.
通讯作者: Huckriede, A.
DOI: 10.1637/8239-013008-reg.1
发表时间: 2008-09-01
期刊: AVIAN DISEASES
影响因子: 1.4
作者:
Dai, Yabin;Liu, Mei;Li, Wenliang
通讯作者: Li, Wenliang