Mouse models in studies on the etiology of evaporative dry eye disease.
Mouse models in studies on the etiology of evaporative dry eye disease.
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DOI：
10.1016/j.exer.2022.109072
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发表时间：
2022-06
影响因子：
3.4
通讯作者：
Golczak, Marcin
中科院分区：
文献类型：
--
作者：
Widjaja-Adhi, Made Airanthi K.;Chao, Karina;Golczak, Marcin
蒸发性干眼病(DED)是一种常见的眼部疾病，影响全球数百万患者的生活质量。蒸发性DED的病因与眉板腺(MGs)功能障碍有关，导致分泌型MEIBUM的产量或脂肪成分不佳。蒸发性DED的临床表现包括MG口机械性阻塞和泪膜稳定性降低，导致慢性眼刺激、炎症和对角膜及周围组织的进行性损害。尽管蒸发性DED的发病率很高，但它仍然是一个未得到满足的医疗需求。制定有效的治疗策略的主要障碍是对MG中复杂的成脂反应(小细胞生成)的了解不足，以及缺乏适合人类状况的动物模型。在这篇综述中，我们讨论了重述蒸发性DED表型的转基因小鼠模型的最新进展，以及它们对我们理解MG中脂质生物合成和针对小细胞发育的治疗策略的影响。
Evaporative dry eye disease (DED) is a common ocular condition impacting the quality of life of millions of patients worldwide. The etiology of evaporative DED is related to dysfunction of meibomian glands (MGs), resulting in suboptimal yield or lipid composition of secreted meibum. The clinical manifestation of evaporative DED involves mechanical obstruction of the MG orifice and decreased tear film stability that leads to chronic eye irritation, inflammation, and progressive damage to the cornea and surrounding tissue. Despite its high prevalence, evaporative DED remains an unmet medical need. The main obstacle in the development of effective therapeutic strategies against this disease is inadequate knowledge about the complex arrays of lipogenic reactions (meibogenesis) in the MGs and a lack of suitable animal models of the human condition. In this review, we discuss the recent advances in the creation of genetically modified mouse models that recapitulate the phenotype of evaporative DED as well as their impact on our understanding of lipid biosynthesis in MGs and therapeutic strategies targeting meibogenesis.
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