Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity.
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity.
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DOI：
10.3389/fncel.2014.00430
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发表时间：
2014
影响因子：
5.3
通讯作者：
Molteni R
中科院分区：
文献类型：
--
作者：
Calabrese F;Rossetti AC;Racagni G;Gass P;Riva MA;Molteni R
细胞因子是参与宿主对免疫挑战的应答的关键调节介质，但也在免疫和中枢神经系统之间的通信中发挥关键作用。为此，它们在两种系统中的表达都处于严格的调控控制之下。然而，病理条件可能导致促炎细胞因子的过度产生，这可能对中枢神经系统具有不利影响。特别是，它们可能损害神经元结构和功能，导致神经可塑性缺陷，神经系统感知，反应和适应外部或内部刺激的能力。在搜索的机制，促炎细胞因子可能会影响这一关键的大脑能力，我们将讨论最有趣的假设之一：参与的神经营养蛋白脑源性神经营养因子（BDNF），这是神经可塑性的主要介质之一。
Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.
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影响因子：
5.3
作者：
Audet MC;Anisman H
通讯作者：
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影响因子：
16.2
作者：
Denny CA;Kheirbek MA;Alba EL;Tanaka KF;Brachman RA;Laughman KB;Tomm NK;Turi GF;Losonczy A;Hen R
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