Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor.

Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor.
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DOI:
10.1371/journal.pone.0187149
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
Lewis SJ
Lewis SJ
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Seckler JM;Meyer NM;Burton ST;Bates JN;Gaston B;Lewis SJ

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Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these molecules difficult. Here we present a method for detecting trace concentrations of S-nitrosothiols in biological fluids. Capacitive sensors when coupled to a semiconducting material represent a method for detecting trace quantities of a chemical in complex solutions. We have taken advantage of the semiconducting and chemical properties of polydopamine to construct a capacitive sensor and associated method of use, which specifically senses S-nitrosothiols in complex biological solutions.
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