Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.
Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.
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DOI：
10.1038/s41467-022-34970-7
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发表时间：
2022-12-12
影响因子：
16.6
通讯作者：
Mather, Alison E.
中科院分区：
文献类型：
--
作者：
Zamudio, Roxana;Boerlin, Patrick;Beyrouthy, Racha;Madec, Jean-Yves;Schwarz, Stefan;Mulvey, Michael R.;Zhanel, George G.;Cormier, Ashley;Chalmers, Gabhan;Bonnet, Richard;Haenni, Marisa;Eichhorn, Inga;Kaspar, Heike;Garcia-Fierro, Raquel;Wood, James L. N.;Mather, Alison E.
超广谱头孢菌素（ESC）是人类和兽医学中非常重要的抗菌药物。ESC抗性（ESC-R）基因通过质粒和克隆扩增在世界范围内传播，但ESC-R基因在不同生态区室中的分布和动态知之甚少。在这里，我们使用全基因组序列数据的Enterocellales分离株的人和动物来源于欧洲和北美，并确定对比的时间动态。AmpC β-内酰胺酶最初在北美的人类和农场动物中占主导地位，后来才在欧洲出现。相比之下，特异性超广谱β-内酰胺酶（ESBLs）最初在欧洲动物中很常见，后来在北美出现。本研究确定了质粒的相对重要性和克隆扩增在不同的隔间不同ESC-R基因的传播的差异。了解传播机制对于设计干预措施以减少抗菌素耐药性的传播至关重要。大肠杆菌中的超广谱头孢菌素耐药基因已在全球范围内传播。在这里，作者剖析了这些基因随时间的出现和分布，以及地理位置和宿主物种，以更好地了解它们的动态和传播机制。
Extended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relative importance of plasmids and clonal expansion across different compartments for the spread of different ESC-R genes. Understanding the mechanisms of transmission will be critical in the design of interventions to reduce the spread of antimicrobial resistance. Extended-spectrum cephalosporin resistance genes in Escherichia coli have spread worldwide. Here, the authors dissect the emergence and distribution of these genes over time, and across geographic location and host species, to better understand their dynamics and mechanisms of transmission.
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影响因子：
4.6
作者：
Duggett N;AbuOun M;Randall L;Horton R;Lemma F;Rogers J;Crook D;Teale C;Anjum MF
通讯作者：
Anjum MF
头头：在增加抗菌素耐药性时代的重新评估。
影响因子：
5.7
作者：
Endimiani A;Perez F;Bonomo RA
通讯作者：
Bonomo RA
影响因子：
3.3
作者：
Cormier, Ashley;Zhang, Pauline L. C.;Boerlin, Patrick
通讯作者：
Boerlin, Patrick
影响因子：
5.2
作者：
Dorado-Garcia, Alejandro;Smid, Joost H.;Heederik, Dick J. J.
通讯作者：
Heederik, Dick J. J.
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS