Circadian system, sleep and endocrinology.
Circadian system, sleep and endocrinology.
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DOI：
10.1016/j.mce.2011.09.003
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发表时间：
2012-02-05
影响因子：
4.1
通讯作者：
Scheer, Frank A. J. L.
中科院分区：
文献类型：
--
作者：
Morris, Christopher J.;Aeschbach, Daniel;Scheer, Frank A. J. L.
各种荷尔蒙的水平在白天和黑夜都不同。这种波动不仅与睡眠/清醒和其他行为的变化有关，还与下丘脑视交叉上核控制的生物计时系统有关。睡眠对生长激素等某些荷尔蒙的水平有很大影响，但对其他受生物计时系统(如褪黑激素)调节较强的荷尔蒙水平影响不大。虽然睡眠影响循环荷尔蒙水平的确切机制知之甚少，但更多的人知道生物计时系统是如何影响荷尔蒙分泌的。视交叉上核通过神经元和体液信号对激素施加影响，但现在也很明显，外周细胞可以有节律性地分泌激素，而不依赖于视交叉上核的信号。在正常情况下，行为和生物计时系统是同步的，因此荷尔蒙系统受到精确的调节。然而，许多个体(例如，轮班工人)通过使他们的睡眠/唤醒周期与生物计时系统去同步而频繁地经历昼夜节律失调。最近的实验表明，昼夜节律失调对新陈代谢和激素因素，如葡萄糖和胰岛素有不利影响。需要进一步的研究来确定导致昼夜节律失调引起的负面影响的潜在机制。这样的研究可以帮助开发针对昼夜节律失调的对策。
Levels of numerous hormones vary across the day and night. Such fluctuations are not only attributable to changes in sleep/wakefulness and other behaviors but also to a biological timing system governed by the suprachiasmatic nucleus of the hypothalamus. Sleep has a strong effect on levels of some hormones such as growth hormone but little effect on others which are more strongly regulated by the biological timing system (e.g., melatonin). Whereas the exact mechanisms through which sleep affects circulating hormonal levels are poorly understood, more is known about how the biological timing system influences the secretion of hormones. The suprachiasmatic nucleus exerts its influence on hormones via neuronal and humoral signals but it is also now apparent that peripheral cells can rhythmically secrete hormones independent of signals from the suprachiasmatic nucleus. Under normal circumstances, behaviors and the biological timing system are synchronized and consequently hormonal systems are exquisitely regulated. However, many individuals (e.g., shift-workers) frequently undergo circadian misalignment by desynchronizing their sleep/wake cycle from the biological timing system. Recent experiments indicate that circadian misalignment has an adverse effect on metabolic and hormonal factors such as glucose and insulin. Further research is needed to determine the underlying mechanisms that cause the negative effects induced by circadian misalignment. Such research could aid the development of countermeasures for circadian misalignment.
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影响因子：
3.7
作者：
BORN, J;MUTH, S;FEHM, HL
通讯作者：
FEHM, HL
影响因子：
6.7
作者：
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影响因子：
10.5
作者：
Akerstedt, T
通讯作者：
Akerstedt, T
影响因子：
3.3
作者：
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通讯作者：
Miyashita, M.
影响因子：
--
作者：
BORN, J;DEKLOET, ER;FEHM, HL
通讯作者：
FEHM, HL