Design and evaluation of quantitative MRI phantoms to mimic the simultaneous presence of fat, iron, and fibrosis in the liver.
Design and evaluation of quantitative MRI phantoms to mimic the simultaneous presence of fat, iron, and fibrosis in the liver.
复制标题
设计和评价定量MRI体模以模拟肝脏中脂肪、铁和纤维化的同时存在。
DOI：
10.1002/mrm.28452
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发表时间：
2021-03
影响因子：
3.3
通讯作者：
Hernando D
中科院分区：
文献类型：
--
作者：
Zhao R;Hamilton G;Brittain JH;Reeder SB;Hernando D
设计、构建和评价模拟肝脏MRI信号的定量MR模型，同时控制三个参数：质子密度脂肪分数（PDFF）、和T1。这些参数分别是肝脂肪变性、铁过载和纤维化/炎症的既定生物标志物，其可以在肝脏中同时发生。构建了包括多个小瓶的样品盒。用花生油调制PDFF，用MnCl 2和铁微球调制，用NiCl 2调制水的T1（T1，水）。使用刺激回波采集模式MR光谱（STEAM-MRS）和化学位移编码（CSE）MRI在1.5T和3.0T下对体模进行了评价。处理STEAM-MRS数据，以估计每个小瓶的T1、水、T1、脂肪和。处理CSE-MRI数据以生成PDFF和图，并在每个小瓶中获得测量值。使用线性回归和Bland-Altman分析评价测量值。获得了高质量的PDFF和图谱，每个小瓶中的值均匀。在1.5T和3.0T下，在成像PDFF与靶PDFF（斜率=0.94-0.97，R2=0.994-0.997）和成像与靶（斜率=0.84-0.88，R2=0.935-0.943）之间观察到高度相关性。 并且在1.5T（斜率=0.90，R2=0.988）和3.0T（斜率=0.99，R2=0.959）下与接近1.0的斜率高度相关，与体内观察到的行为相似。T1，水（500- 1200 ms）受不同NiCl 2浓度控制，而T1，脂肪（300 ms）不受NiCl 2浓度的影响。成功开发并验证了模拟肝脏中脂肪、铁和纤维化同时存在的新型定量MRI体模。定量成像生物标志物，体模，质子密度脂肪分数，T1，肝脏
To design, construct, and evaluate quantitative MR phantoms that mimic MRI signals from the liver with simultaneous control of three parameters: proton-density fat-fraction (PDFF), , and T1. These parameters are established biomarkers of hepatic steatosis, iron overload, and fibrosis/inflammation, respectively, which can occur simultaneously in the liver. Phantoms including multiple vials were constructed. Peanut oil was used to modulate PDFF, MnCl2 and iron microspheres were used to modulate , and NiCl2 was used to modulate the T1 of water (T1,water). Phantoms were evaluated at both 1.5T and 3.0T using stimulated echo acquisition mode MR spectroscopy (STEAM-MRS) and chemical shift encoded (CSE) MRI. STEAM-MRS data were processed to estimate T1,water, T1,fat, , and for each vial. CSE-MRI data were processed to generate PDFF and maps, and measurements were obtained in each vial. Measurements were evaluated using linear regression and Bland-Altman analysis. High quality PDFF and maps were obtained with homogeneous values throughout each vial. High correlation was observed between imaging PDFF with target PDFF (slope=0.94–0.97, R2=0.994–0.997) and imaging with target (slope=0.84–0.88, R2=0.935–0.943) at both 1.5T and 3.0T. and were highly correlated with slope close to 1.0 at both 1.5T (slope=0.90, R2=0.988) and 3.0T (slope=0.99, R2=0.959), similar to the behavior observed in vivo. T1,water (500–1200ms) was controlled with varying NiCl2 concentration, while T1,fat (300ms) was independent of NiCl2 concentration. Novel quantitative MRI phantoms that mimic the simultaneous presence of fat, iron, and fibrosis in the liver were successfully developed and validated. Quantitative imaging biomarkers, phantom, proton-density fat-fraction, , T1, liver
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影响因子：
4.4
作者：
Mozes, Ferenc E.;Tunnicliffe, Elizabeth M.;Robson, Matthew D.
通讯作者：
Robson, Matthew D.
影响因子：
3.3
作者：
Hernando, D.;Hines, C. D. G.;Yu, H.;Reeder, S. B.
通讯作者：
Reeder, S. B.
影响因子：
4.4
作者：
Hines, Catherine D. G.;Agni, Rashmi;Roen, Calista;Rowland, Ian;Hernando, Diego;Bultman, Eric;Horng, Debra;Yu, Huanzhou;Shimakawa, Ann;Brittain, Jean H.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
4.4
作者：
Horng, Debra E.;Hernando, Diego;Hines, Catherine D. G.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
DOI：
10.1186/s12968-016-0308-4
发表时间：
2016-11-30
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Haaf P;Garg P;Messroghli DR;Broadbent DA;Greenwood JP;Plein S
通讯作者：
Plein S