Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?
Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?
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DOI：
10.1186/s13071-022-05401-9
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发表时间：
2022-08-09
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
埃及伊蚊（Aedes aegypti）和白纹伊蚊（Aedes albopictus）是人类高致病性病毒的主要载体，例如登革热（DENV）、基孔肯雅热（CHIKV）和寨卡病毒（ZIKV），这些病毒引起发热、出血和神经系统疾病，并且仍然是对全球公共卫生的主要威胁。高生态可塑性，机会主义的喂养模式，以及在城市和自然繁殖地的使用这些载体的多功能性，有利于他们在热带，亚热带，甚至温带地区的传播和适应。由于缺乏可用的治疗方法和疫苗，控制蚊子数量是预防虫媒病毒疾病的最有效方法。常驻微生物通过阻止或增强其传播病毒病原体的媒介能力在宿主适应性中起着至关重要的作用。高通量测序和宏基因组分析推进了我们对伊蚊属微生物的组成和功能的理解。有趣的是，鸟枪宏基因组学研究已经确定蚊子载体具有由昆虫特异性病毒（ISV）组成的高度保守的病毒组。虽然ISV对脊椎动物没有感染性，但它们可以改变虫媒病毒周期的不同阶段，干扰向人类宿主的传播。因此，本文将重点介绍Ae的描述。aegypti和Ae.白纹伊蚊作为易受病毒病原体感染的媒介，突出了微生物群-病毒组在媒介能力中的作用及其在新出现和重新出现的虫媒病毒控制策略中的潜力。
Aedes aegypti and Aedes albopictus are the main vectors of highly pathogenic viruses for humans, such as dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which cause febrile, hemorrhagic, and neurological diseases and remain a major threat to global public health. The high ecological plasticity, opportunistic feeding patterns, and versatility in the use of urban and natural breeding sites of these vectors have favored their dispersal and adaptation in tropical, subtropical, and even temperate zones. Due to the lack of available treatments and vaccines, mosquito population control is the most effective way to prevent arboviral diseases. Resident microorganisms play a crucial role in host fitness by preventing or enhancing its vectorial ability to transmit viral pathogens. High-throughput sequencing and metagenomic analyses have advanced our understanding of the composition and functionality of the microbiota of Aedes spp. Interestingly, shotgun metagenomics studies have established that mosquito vectors harbor a highly conserved virome composed of insect-specific viruses (ISV). Although ISVs are not infectious to vertebrates, they can alter different phases of the arboviral cycle, interfering with transmission to the human host. Therefore, this review focuses on the description of Ae. aegypti and Ae. albopictus as vectors susceptible to infection by viral pathogens, highlighting the role of the microbiota-virome in vectorial competence and its potential in control strategies for new emerging and re-emerging arboviruses.
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影响因子：
3
作者：
Coleman M;Hemingway J;Gleave KA;Wiebe A;Gething PW;Moyes CL
通讯作者：
Moyes CL
影响因子：
3.2
作者：
da Costa CF;Dos Passos RA;Lima JBP;Roque RA;de Souza Sampaio V;Campolina TB;Secundino NFC;Pimenta PFP
通讯作者：
Pimenta PFP
影响因子：
4.8
作者：
Cholleti H;Hayer J;Fafetine J;Berg M;Blomström AL
通讯作者：
Blomström AL
影响因子：
2.1
作者：
Braks, MAH;Honório, NA;Lounibos, LP
通讯作者：
Lounibos, LP
影响因子：
3.7
作者：
Apte-Deshpande A;Paingankar M;Gokhale MD;Deobagkar DN
通讯作者：
Deobagkar DN