Amplitude of low-frequency oscillations in first-episode, treatment-naive patients with major depressive disorder: a resting-state functional MRI study.
Amplitude of low-frequency oscillations in first-episode, treatment-naive patients with major depressive disorder: a resting-state functional MRI study.
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首发、未接受治疗的重度抑郁症患者的低频振荡幅度：一项静息态功能 MRI 研究。
DOI：
10.1371/journal.pone.0048658
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Si T
中科院分区：
文献类型：
--
作者：
Wang L;Dai W;Su Y;Wang G;Tan Y;Jin Z;Zeng Y;Yu X;Chen W;Wang X;Si T
静息态功能磁共振成像是一种新的方法来测量自发脑活动的抑郁症（MDD）患者。虽然大多数静息态fMRI研究都集中在检查低频振荡（LFOs）之间的时间相关性，很少有研究探讨这些LFOs在MDD的振幅。在本研究中，我们应用低频波动幅度（ALFF）和分数ALFF的方法来研究MDD中LFO的幅度。共有36名受试者，18名首次发作，治疗初治的MDD患者与18名健康对照（HC）完成了fMRI扫描。与HC相比，MDD患者右侧梭状回和右侧小脑前、后叶的ALFF增加，左侧颞下回、双侧顶下小叶和右侧舌回的ALFF减少。患者的fALFF在右侧中央前回、右侧颞下回、双侧梭状回和双侧小脑前后叶显著增加，而在左侧背外侧前额叶皮质、双侧内侧眶额皮质、双侧颞中回、左侧颞下回和右侧顶下小叶显著减少。以脑灰质体积为协变量后，结果仍保持不变。这些发现表明，MDD患者在额叶、颞叶、顶叶、枕叶皮质和小脑的许多区域都改变了LFO振幅。这些异常区域可能与MDD中观察到的多种情绪和认知相关网络的紊乱以及抑郁症状领域的明显异质性有关。这种MDD的脑功能改变可能有助于进一步了解MDD相关的网络失衡在以前的fMRI研究中表现出来。
Resting-state fMRI is a novel approach to measure spontaneous brain activity in patients with major depressive disorder (MDD). Although most resting-state fMRI studies have focused on the examination of temporal correlations between low-frequency oscillations (LFOs), few studies have explored the amplitude of these LFOs in MDD. In this study, we applied the approaches of amplitude of low-frequency fluctuation (ALFF) and fractional ALFF to examine the amplitude of LFOs in MDD. A total of 36 subjects, 18 first-episode, treatment-naive patients with MDD matched with 18 healthy controls (HCs) completed the fMRI scans. Compared with HCs, MDD patients showed increased ALFF in the right fusiform gyrus and the right anterior and posterior lobes of the cerebellum but decreased ALFF in the left inferior temporal gyrus, bilateral inferior parietal lobule, and right lingual gyrus. The fALFF in patients was significantly increased in the right precentral gyrus, right inferior temporal gyrus, bilateral fusiform gyrus, and bilateral anterior and posterior lobes of the cerebellum but was decreased in the left dorsolateral prefrontal cortex, bilateral medial orbitofrontal cortex, bilateral middle temporal gyrus, left inferior temporal gyrus, and right inferior parietal lobule. After taking gray matter (GM) volume as a covariate, the results still remained. These findings indicate that MDD patients have altered LFO amplitude in a number of regions distributed over the frontal, temporal, parietal, and occipital cortices and the cerebellum. These aberrant regions may be related to the disturbances of multiple emotion- and cognition-related networks observed in MDD and the apparent heterogeneity in depressive symptom domains. Such brain functional alteration of MDD may contribute to further understanding of MDD-related network imbalances demonstrated in previous fMRI studies.
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