The spiral axis: A comparison of unaffected first-degree relatives of essential tremor cases vs. controls.
The spiral axis: A comparison of unaffected first-degree relatives of essential tremor cases vs. controls.
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DOI：
10.1016/j.jns.2021.117330
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发表时间：
2021-03-15
影响因子：
4.4
通讯作者：
Elkurd M
中科院分区：
文献类型：
--
作者：
Louis ED;Dowd HN;Elkurd M
我们以前观察到，在螺旋绘制任务中，在特发性震颤(ET)的情况下，震颤波形沿单一主轴排列。这一有趣的临床特征可以区分ET和肌张力障碍病例。我们现在调查ET病例的未受影响的亲属是否也表现出这种特征，尽管可能是以较温和的形式。为了达到我们的目的，我们评估了237例未受影响的ET患者一级亲属(FD-ET)的螺旋轴，并将他们与105名对照组(Co)进行了比较。一位运动障碍神经科医生评估了四个手绘螺旋线是否存在单一可识别的震颤定向轴。每个参与者都被分配了一个螺旋轴分数(范围=0-4[4个螺旋线上的一个单轴])。在列联表中，两组螺旋轴得分的分布不同：FD-ET(最高)和Co(最低)(顺序卡方检验p=0.014)。此外，当螺旋轴评分作为一个连续测量时，两组之间存在差异(Mann-Whitney检验p=0.03)--平均值分别为0.51(FD-ET)和0.26(Co)。这些数据具有科学意义。他们(1)表明这样的轴在ET患者的亲属中比对照组更常见，(2)提出螺旋轴可能是ET的早期亚临床特征。
We previously observed that during a spiral drawing task, in essential tremor (ET) cases, the tremor wave forms align along a single predominant axis. This interesting clinical feature can distinguish ET from dystonia cases. We now investigate whether the unaffected relatives of ET cases also express this trait, albeit perhaps in a milder form. To address our aim, we assessed the spiral axis in 237 unaffected first-degree relatives of ET cases (FD-ET), comparing them to 105 controls (Co). A movement disorder neurologist assessed four hand drawn spirals for the presence of a single identifiable tremor orientation axis. A spiral axis score (range = 0 – 4 [a single axis on 4 spirals]) was assigned to each enrollee. FD-ET had higher spiral axis scores than Co. In a contingency table, the distribution of spiral axis scores differed in the two groups: FD-ET (highest) and Co (lowest) (ordinal chi-square test p = 0.014). Furthermore, when spiral axis scores were examined as a continuous measure, the groups differed (Mann-Whitney test p = 0.03) - with the means being 0.51 (FD-ET) and 0.26 (Co). These data have scientific implications. They (1) show that such axes are more common in relatives of ET cases than controls, and (2) raise the possibility that the spiral axis may be an early subclinical feature of ET.
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影响因子：
2.7
作者：
Sengul, Yildizhan;Sengul, Hakan S.;Ozdemir, Gokhan
通讯作者：
Ozdemir, Gokhan
DOI：
10.1002/mds.23674
发表时间：
2011-07
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Louis ED;Hafeman D;Parvez F;Liu X;Alcalay RN;Islam T;Ahmed A;Siddique AB;Patwary TI;Melkonian S;Argos M;Levy D;Ahsan H
通讯作者：
Ahsan H
影响因子：
9.9
作者：
Benito-León, J;Louis, ED;Bermejo-Pareja, F
通讯作者：
Bermejo-Pareja, F
影响因子：
3.4
作者：
Hale, Evan A.;Hickman, Ruby;Louis, Elan D.
通讯作者：
Louis, Elan D.
影响因子：
5.7
作者：
Louis, Elan D.;Cubo, Esther;Benito-Leon, Julian
通讯作者：
Benito-Leon, Julian