Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults.
Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults.
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DOI：
10.1002/mds.23674
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Ahsan H
中科院分区：
文献类型：
--
作者：
Louis ED;Hafeman D;Parvez F;Liu X;Alcalay RN;Islam T;Ahmed A;Siddique AB;Patwary TI;Melkonian S;Argos M;Levy D;Ahsan H
大多数正常人都会发生轻微的动作性震颤。然而，这种震颤主要是在高龄背景下进行的研究，而不是在绝大多数非老年人的背景下进行研究。这种震颤在中青年时期是否会恶化还不得而知。使用一项基于人群的大型中青年(18-60岁)正常成人研究的横断面数据，我们评估了年龄增长是否与更严重的动作震颤有关。在孟加拉国的阿拉哈扎尔，2524名成年人用双手画了一个阿基米德螺旋。由盲人神经科医生对螺旋状震颤进行评分(0-3)，并对螺旋状震颤进行评分(范围为0-6)。螺旋积分与年龄呈正相关(r=0.06，p=0.004)。随着年龄的增加，螺旋得分增加(p=0.002)，因此最高年龄组(60岁)参与者的螺旋得分大约是最小年龄组(18-19岁)参与者的两倍(p=0.003)。在调整了潜在混杂因素(性别、香烟、药物、哮喘吸入器、茶和槟榔的使用)的回归模型中，螺旋评分与年龄有关(p=0.0045)。在这项基于人群的横断面研究中，对2500名中青年正常成年人进行了研究，发现年龄和震颤严重程度之间存在明显的关联。尽管相关系数的大小不大，但震颤的严重程度每十年都在上升。这些数据表明，与年龄相关的震颤幅度的增加并不局限于老年人，而是发生在所有成年年龄段。
Mild action tremor occurs in most normal people. Yet this tremor mainly has been studied within the context of advanced age rather than the vast bulk of adults who are not elderly. Whether this tremor worsens during young and middle age is unknown. Using cross-sectional data from a large population-based study of young and midlife (ages 18 – 60) normal adults, we assessed whether increasing age is associated with more severe action tremor. 2,524 adults in Araihazar, Bangladesh drew an Archimedes spiral with each hand. Tremor in spirals was rated (0 - 3) by a blinded neurologist and a spiral score (range, 0 – 6) was assigned. Spiral score was correlated with age (r = 0.06, p = 0.004). With each advancing decade, the spiral score increased (p = 0.002) so that the spiral score in participants in the highest age group (age 60) was approximately twice that of participants in the youngest age group (18-19 years)(p = 0.003). In the regression model that adjusted for potential confounders (gender, cigarettes, medications, asthma inhalers, tea and betel nut use), spiral score was associated with age (p = 0.0045). In this cross-sectional, population-based study of >2,500 young and mid-life normal adults, there was a clear association between age and tremor severity. Although the magnitude of the correlation coefficient was modest, tremor severity was higher with each passing decade. These data suggest that age-dependent increase in tremor amplitude is not restricted to older people, but occurs in all adult age groups.
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影响因子：
5.7
作者：
Louis, Elan D.;Thawani, Sujata P.;Andrews, Howard F.
通讯作者：
Andrews, Howard F.
影响因子：
3.4
作者：
Louis, Elan D.
通讯作者：
Louis, Elan D.
DOI：
10.1038/sj.jea.7500449
发表时间：
2006-03-01
影响因子：
4.5
作者：
Ahsan, H;Chen, Y;Graziano, J
通讯作者：
Graziano, J
影响因子：
3.7
作者：
Kalisch, Tobias;Wilimzig, Claudia;Dinse, Hubert R.
通讯作者：
Dinse, Hubert R.
影响因子：
3.5
作者：
Louis, ED;Wendt, KJ;Ford, B
通讯作者：
Ford, B