Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.
Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.
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DOI：
10.1002/oby.20796
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发表时间：
2014-09
期刊：
影响因子：
6.9
通讯作者：
Chaturvedi, Nishi
中科院分区：
文献类型：
--
作者：
Eastwood, Sophie V.;Tillin, Therese;Wright, Andrew;Mayet, Jamil;Godsland, Ian;Forouhi, Nita G.;Whincup, Peter;Hughes, Alun D.;Chaturvedi, Nishi
比较南亚人和欧洲人的脂肪分布和脂肪库与心脏代谢特征之间的关联。514名南亚人和669名欧洲人，年龄在56-86岁之间。通过问卷、记录回顾、血液检测和冠状动脉钙化评分提供糖尿病和临床加亚临床冠心病（CHD）诊断。通过CT测量腹部内脏脂肪（VAT）和皮下脂肪组织、大腿皮下脂肪组织（TSAT）、大腿肌间脂肪和肌内脂肪以及大腿肌肉。考虑到体型，南亚人的VAT和TSAT比欧洲人高，但大腿肌肉少。在南亚人中，仓库与疾病之间的关联比欧洲人更强。在南亚人的多变量分析中，VAT与糖尿病和CHD呈正相关，而TSAT和大腿肌肉对糖尿病有保护作用，而大腿肌肉对CHD有保护作用。VAT和大腿肌肉的差异只能部分解释南亚人与欧洲人相比的糖尿病和冠心病。胰岛素抵抗并不能解释TSAT或大腿肌肉的影响。南亚人较高的VAT和TSAT以及较少的大腿肌肉导致了心脏代谢疾病的种族差异。TSAT和大腿肌肉的作用独立于胰岛素抵抗。
To compare fat distribution and associations between fat depots and cardiometabolic traits in South Asians and Europeans. Five hundred and fourteen South Asians and 669 Europeans, aged 56-86. Questionnaires, record review, blood testing, and coronary artery calcification scores provided diabetes and clinical plus subclinical coronary heart disease (CHD) diagnoses. Abdominal visceral (VAT) and subcutaneous adipose tissue, thigh subcutaneous adipose tissue (TSAT), intermuscular and intramuscular thigh fat and thigh muscle were measured by CT. Accounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle. Associations between depots and disease were stronger in South Asians than Europeans. In multivariable analyses in South Asians, VAT was positively associated with diabetes and CHD, while TSAT and thigh muscle were protective for diabetes, and thigh muscle for CHD. Differences in VAT and thigh muscle only partially explained the excess diabetes and CHD in South Asians versus Europeans. Insulin resistance did not account for the effects of TSAT or thigh muscle. Greater VAT and TSAT and lesser thigh muscle in South Asians contributed to ethnic differences in cardiometabolic disease. Effects of TSAT and thigh muscle were independent of insulin resistance.
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影响因子：
6.9
作者：
Dube, Marie-Christine;Lemieux, Simone;Weisnagel, Stanley J.
通讯作者：
Weisnagel, Stanley J.
影响因子：
16.2
作者：
Mostafa SA;Davies MJ;Webb DR;Srinivasan BT;Gray LJ;Khunti K
通讯作者：
Khunti K
影响因子：
5.8
作者：
Goodpaster, BH;He, J;Kelley, DE
通讯作者：
Kelley, DE
影响因子：
8.9
作者：
Rumberger, JA;Brundage, BH;Kondos, G
通讯作者：
Kondos, G
影响因子：
8.2
作者：
Snijder, MB;Visser, M;Seidell, JC
通讯作者：
Seidell, JC