Regulation of gene expression in human tendinopathy.
Regulation of gene expression in human tendinopathy.
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DOI：
10.1186/1471-2474-12-86
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发表时间：
2011-05-03
影响因子：
2.3
通讯作者：
Seeherman HJ
中科院分区：
文献类型：
--
作者：
Jelinsky SA;Rodeo SA;Li J;Gulotta LV;Archambault JM;Seeherman HJ
慢性肌腱损伤，也称为肌腱病，在职业和休闲运动员中很常见。这些损伤导致大量的发病率和医疗保健支出，但人们对导致肌腱病的分子机制知之甚少。我们使用组织学评估和分子分析来确定 23 名接受外科手术治疗慢性肌腱病的患者的基因表达变化。患病肌腱表现出细胞外基质改变、纤维定向障碍、细胞含量和脉管系统增加以及炎症细胞缺失。全局基因表达谱鉴定出 983 个转录本，在患病肌腱中具有显着不同的表达模式。全局通路分析进一步表明细胞外基质蛋白的表达发生改变并且缺乏明显的炎症反应。鉴定肌腱病样本中差异调节的途径和基因将有助于我们对该疾病的理解和新疗法的开发。
Chronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure, yet little is known about the molecular mechanisms leading to tendinopathy. We have used histological evaluation and molecular profiling to determine gene expression changes in 23 human patients undergoing surgical procedures for the treatment of chronic tendinopathy. Diseased tendons exhibit altered extracellular matrix, fiber disorientation, increased cellular content and vasculature, and the absence of inflammatory cells. Global gene expression profiling identified 983 transcripts with significantly different expression patterns in the diseased tendons. Global pathway analysis further suggested altered expression of extracellular matrix proteins and the lack of an appreciable inflammatory response. Identification of the pathways and genes that are differentially regulated in tendinopathy samples will contribute to our understanding of the disease and the development of novel therapeutics.
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影响因子：
2.8
作者：
Eriksen, HA;Pajala, A;Risteli, J
通讯作者：
Risteli, J
DOI：
10.3109/17453679709004002
发表时间：
1997-04-01
期刊：
ACTA ORTHOPAEDICA SCANDINAVICA
影响因子：
--
作者：
Movin, T;Gad, A;Rolf, C
通讯作者：
Rolf, C
影响因子：
4.4
作者：
Khodoun, Marat;Lewis, Christina;Finkelman, Fred D.
通讯作者：
Finkelman, Fred D.
影响因子：
4.2
作者：
Jelinsky, Scott A.;Lake, Spencer P.;Archambault, Joanne M.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
DOI：
10.1034/j.1600-0838.2000.010006312.x
发表时间：
2000-12-01
影响因子：
4.1
作者：
Kannus, P
通讯作者：
Kannus, P