Early neglect is associated with alterations in white matter integrity and cognitive functioning.
Early neglect is associated with alterations in white matter integrity and cognitive functioning.
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DOI：
10.1111/cdev.12069
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发表时间：
2013-09
影响因子：
4.6
通讯作者：
Pollak SD
中科院分区：
文献类型：
--
作者：
Hanson JL;Adluru N;Chung MK;Alexander AL;Davidson RJ;Pollak SD
据报道，经历过早期忽视的儿童，特别是在机构环境中长大的儿童，会出现认知缺陷。先前的研究表明，早期忽视可能会对前额叶皮层（PFC）中白色物质的方向组织产生不同的影响。这可能是解释与忽视相关的认知缺陷的一种机制。为了验证这一观点，对早期忽视儿童和在典型环境中长大的儿童（n=63，平均年龄=11.75岁）的白色物质和神经认知性能进行了评估。正如预测的那样，在遭受早期忽视的儿童中，前额叶白色物质微结构受到影响，与更弥散的组织一致，这与神经认知缺陷有关。这些发现强调了早期逆境如何影响PFC，并解释了与忽视相关的认知缺陷。
Cognitive deficits have been reported in children who experienced early neglect, especially children raised in institutionalized settings. Previous research suggests early neglect may differentially affect the directional organization of white matter in the prefrontal cortex (PFC). This may be one mechanism to explain cognitive deficits associated with neglect. To test this idea, properties of white matter and neurocognitive performance was assessed in children who suffered early neglect and those raised in typical environments (n=63, Mean Age=11.75 years). As predicted, prefrontal white matter microstructure was affected, consistent with more diffuse organization, in children that suffered early neglect and this was related to neurocognitive deficits. Such findings underscore how early adversity may affect the PFC and explain cognitive deficits associated with neglect.
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影响因子：
34.7
作者：
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通讯作者：
Arnsten, Amy F. T.
影响因子：
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作者：
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通讯作者：
Pfefferbaum, Adolf
DOI：
10.1111/j.1540-5834.2010.00553.x
发表时间：
2010-01-01
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影响因子：
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