MR diffusion tensor imaging: a window into white matter integrity of the working brain.

MR diffusion tensor imaging: a window into white matter integrity of the working brain.
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DOI:
10.1007/s11065-010-9129-7
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发表时间:
2010-06
影响因子:
5.8
通讯作者:
Pfefferbaum, Adolf
Pfefferbaum, Adolf
中科院分区:
心理学2区
文献类型:
--
作者:
Chanraud, Sandra;Zahr, Natalie;Sullivan, Edith V.;Pfefferbaum, Adolf

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正如诺曼·格施温德(Norman Geschwind)在1965年所断言的那样,由白色物质损伤引起的综合征可能会导致高级功能的缺陷,而“连接障碍”或灰质区域之间连接的中断可能会像这些区域本身的创伤一样具有破坏性。体内扩散张量成像技术的出现,使得白色物质纤维的完整性在健康和疾病的定量表征,已经加强了Geschwind的建议。在这里,我们提出了一个概述的原则,扩散张量成像(DTI)和它的贡献进展,我们目前的理解正常和病理性脑功能。
As Norman Geschwind asserted in 1965, syndromes resulting from white matter lesions could produce deficits in higher-order functions and “disconnexion” or the interruption of connection between gray matter regions could be as disruptive as trauma to those regions per se. The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white matter fiber integrity in health and disease, has served to strengthen Geschwind's proposal. Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.
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