Abnormal fronto-striatal connectivity in children with histories of early deprivation: A diffusion tensor imaging study.
Abnormal fronto-striatal connectivity in children with histories of early deprivation: A diffusion tensor imaging study.
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DOI：
10.1007/s11682-009-9071-6
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发表时间：
2009-09
影响因子：
3.2
通讯作者：
Chugani, Harry T.
中科院分区：
文献类型：
--
作者：
Behen, Michael E.;Muzik, Otto;Saporta, Anita S. D.;Wilson, Benjamin J.;Pai, Darshan;Hua, Jing;Chugani, Harry T.
注意力不集中/过度活跃（I/O）的行为表型已被报道在一个显着的百分比从出生在孤儿院提出的儿童。虽然许多研究已经确定了从出生到长大的儿童的功能和结构性脑异常，但没有发表的研究评估了I/O表型的潜在神经相关性。我们对15名在东欧或亚洲的孤儿院长大，后来被收养到美国的青少年前儿童进行了弥散张量成像（DTI）。纤维束构建从DTI数据使用概率纤维跟踪和皮质纤维分布的纤维起源于头的尾状核之间的早期剥夺（艾德）组和12个年龄匹配的控制进行了比较。艾德组表现出更弥散的连接模式，特别是在右半球，可能与发育过程中不完全的神经元修剪有关。这些结构异常可能与ED儿童的注意力不集中和过度活跃有关。
An Inattentive/Overactive (I/O) behavioral phenotype has been reported in a significant percentage of children raised from birth in orphanages. While a number of studies have identified both functional and structural brain abnormalities in children raised from birth in orphanages, no published studies have evaluated potential neural correlates of the I/O phenotype. We applied diffusion tensor imaging (DTI) to 15 pre-teen children raised in orphanages in Eastern Europe or Asia and later adopted to the US. Fiber tracts were constructed from DTI data using probabilistic fiber tracking and the cortical fiber distribution of fibers originating from the head of the caudate was compared between the early deprivation (ED) group and 12 age-matched controls. The ED group showed a more diffuse connectivity pattern, especially in the right hemisphere, potentially related to incomplete neuronal pruning during development. These structural abnormalities may be associated with inattention and overactivity encountered in children with ED.
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