Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer.
Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer.
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DOI：
10.1038/sj.bjc.6604001
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发表时间：
2007-10-22
影响因子：
8.8
通讯作者：
Nielsen K
中科院分区：
文献类型：
--
作者：
Nedergaard BS;Ladekarl M;Thomsen HF;Nyengaard JR;Nielsen K
本研究的目的是探讨宫颈鳞癌原发原位细胞免疫反应的预后价值。对1990年至2000年间接受IB期和IIA期疾病治疗的102名妇女进行了研究。在诊断时处理的石蜡包埋的宫颈组织进行CD3+(T细胞)、CD4+(T辅助/调节性T细胞)和CD8+(细胞毒性T细胞)的免疫染色。免疫细胞谱密度用体视学方法估计。对瘤内和瘤周细胞密度进行了估算。使用Cox的比例风险回归模型，我们发现细胞密度的增加可以降低所有三种细胞类型的复发风险。肿瘤周围CD3+细胞的密度似乎是预测复发的最大潜力。CD3+细胞密度从每平方毫米795个增加到2043个(25%-75%)，危险比降低到0.27。
The purpose of this study was to investigate the prognostic value of the primary in situ cellular immune response in cervical squamous cell carcinoma. A study of 102 women treated for stage IB and IIA disease, between 1990 and 2000, was performed. Paraffin-embedded cervical tissue processed at the time of diagnosis was immunostained for CD3+ (T cells), CD4+ (T helper/regulatory T cells) and CD8+ (cytotoxic T cells) cells. Immune cell profile densities were estimated using stereology. Both intra- and peritumoural cell densities were estimated. Using Cox's proportional hazards regression modelling we found an increase in cell density to decrease the risk of relapse for all three cell types. The density of peritumoural CD3+ cells seems to have the strongest potential for predicting relapse. An increase in CD3+ cell density from 795 to 2043 cells per mm2 (25–75 percentile) reduced the hazard ratio to 0.27.
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DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
5.3
作者：
Johnson, SK;Kerr, KM;Jeffrey, RR
通讯作者：
Jeffrey, RR
影响因子：
5
作者：
Bosch, FX;Muñoz, N
通讯作者：
Muñoz, N
影响因子：
4.5
作者：
Bethwaite, PB;Holloway, LJ;Delahunt, B
通讯作者：
Delahunt, B