Novel hybrid total artificial heart with integrated oxygenator.
Novel hybrid total artificial heart with integrated oxygenator.
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DOI：
10.1111/jocs.17210
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发表时间：
2022-12
影响因子：
1.6
通讯作者：
Throckmorton, Amy L. L.
中科院分区：
文献类型：
--
作者：
Chopski, Steven G. G.;Govender, Krianthan;May, Alexandra;Garven, Ellen;Stevens, Randy M. M.;Tchantchaleishvili, Vakhtang;Throckmorton, Amy L. L.
对于呼吸窘迫和肺部疾病的替代治疗策略，仍然存在未满足的治疗需求。我们正在开发一种便携式心肺支持系统，它将植入式氧合器与混合、双支持、连续流全人工心脏（TAH）集成在一起。TAH具有围绕轴流泵旋转的离心泵。通过将氧合器的中空纤维束连接到TAH的基部，我们建立了一种新的心肺支持技术，允许患者在使用期间走动。在这项研究中，我们研究了设计和改进的血流通道，从流入到流出的四个氧合器使用的数学模型和计算流体动力学（CFD）。检查压力损失和通过扩散的气体输送，以评估氧合器设计。氧合器设计导致阻力驱动的压力损失范围小于35 mmHg，流速为1-7 L/min。所有设计均符合要求。发现具有由外向内血流方向的配置具有较高的氧输送。基于这种有利的流向，将两种设计（模型1和模型3）与TAH轴流式叶轮集成进行模拟。分析1-7 L/min的流速和10，000 - 16，000 RPM的速度。进行了血液损伤研究，模型1表现出最低的溶血可能性。未来的工作将集中在开发和测试一个物理原型集成到新的心肺辅助系统。
There continues to be an unmet therapeutic need for an alternative treatment strategy for respiratory distress and lung disease. We are developing a portable cardiopulmonary support system that integrates an implantable oxygenator with a hybrid, dual-support, continuous-flow total artificial heart (TAH). The TAH has a centrifugal flow pump that is rotating about an axial flow pump. By attaching the hollow fiber bundle of the oxygenator to the base of the TAH, we establish a new cardiopulmonary support technology that permits a patient to be ambulatory during usage. In this study, we investigated the design and improvement of the blood flow pathway from the inflow-to-outflow of four oxygenators using a mathematical model and computational fluid dynamics (CFD). Pressure loss and gas transport through diffusion were examined to assess oxygenator design. The oxygenator designs led to a resistance-driven pressure loss range of less than 35 mmHg for flow rates of 1–7 L/min. All of the designs met requirements. The configuration having an outside-to-inside blood flow direction was found to have higher oxygen transport. Based on this advantageous flow direction, two designs (Model 1 and 3) were then integrated with the axial-flow impeller of the TAH for simulation. Flow rates of 1–7 L/min and speeds of 10,000–16,000 RPM were analyzed. Blood damage studies were performed, and Model 1 demonstrated the lowest potential for hemolysis. Future work will focus on developing and testing a physical prototype for integration into the new cardiopulmonary assist system.
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影响因子：
2.4
作者：
Fox, Carson;Chopski, Steven;Throckmorton, Amy
通讯作者：
Throckmorton, Amy
影响因子：
2.4
作者：
Paul, R;Apel, J;Reul, H
通讯作者：
Reul, H
影响因子：
2.4
作者：
Gage, KL;Gartner, MJ;Wagner, WR
通讯作者：
Wagner, WR
影响因子：
2.4
作者：
Graefe, Roland;Borchardt, Ralf;Steinseifer, Ulrich
通讯作者：
Steinseifer, Ulrich
影响因子：
2.4
作者：
Blauvelt DG;Abada EN;Oishi P;Roy S
通讯作者：
Roy S