Nanobodies for Medical Imaging: About Ready for Prime Time?
Nanobodies for Medical Imaging: About Ready for Prime Time?
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DOI：
10.3390/biom11050637
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发表时间：
2021-04-26
期刊：
影响因子：
5.5
通讯作者：
Rashidian M
中科院分区：
文献类型：
--
作者：
Berland L;Kim L;Abousaway O;Mines A;Mishra S;Clark L;Hofman P;Rashidian M
医学治疗的最新进展在塑造患者，特别是癌症患者的管理和治疗前景方面具有革命性。在过去的十年中，患有各种形式的局部晚期或转移性癌症的患者，如黑色素瘤，肺癌和许多血液传播的恶性肿瘤，他们的预期寿命显着增加。尽管有这些令人鼓舞的结果，但目前这些治疗方法的斗争涉及那些基本上没有反应的患者，以及那些经历严重毒副作用的患者。深入了解这些可变反应背后的细胞和分子机制将使我们更接近开发更有效的治疗方法。为了评估这些机制，非侵入性成像技术提供了有价值的全身信息和精确的靶向。这样的一个例子是免疫PET（正电子发射断层扫描），其采用放射性标记的抗体来检测感兴趣的特定分子。纳米抗体作为最小的衍生抗体片段，具有用于此目的的理想特性，因此已广泛用于临床前模型，最近还用于临床早期研究。它们的优点源于它们对靶点的高亲和力和特异性等因素。此外，它们的小尺寸（约14 kDa）使它们能够容易地通过血流分散，并以可靠和均匀的方式到达组织。在这篇综述中，我们将讨论纳米抗体强大的成像潜力，主要是通过成像恶性肿瘤的透镜，但也触及他们的能力，成像更广泛的各种非恶性疾病。
Recent advances in medical treatments have been revolutionary in shaping the management and treatment landscape of patients, notably cancer patients. Over the last decade, patients with diverse forms of locally advanced or metastatic cancer, such as melanoma, lung cancers, and many blood-borne malignancies, have seen their life expectancies increasing significantly. Notwithstanding these encouraging results, the present-day struggle with these treatments concerns patients who remain largely unresponsive, as well as those who experience severely toxic side effects. Gaining deeper insight into the cellular and molecular mechanisms underlying these variable responses will bring us closer to developing more effective therapeutics. To assess these mechanisms, non-invasive imaging techniques provide valuable whole-body information with precise targeting. An example of such is immuno-PET (Positron Emission Tomography), which employs radiolabeled antibodies to detect specific molecules of interest. Nanobodies, as the smallest derived antibody fragments, boast ideal characteristics for this purpose and have thus been used extensively in preclinical models and, more recently, in clinical early-stage studies as well. Their merit stems from their high affinity and specificity towards a target, among other factors. Furthermore, their small size (~14 kDa) allows them to easily disperse through the bloodstream and reach tissues in a reliable and uniform manner. In this review, we will discuss the powerful imaging potential of nanobodies, primarily through the lens of imaging malignant tumors but also touching upon their capability to image a broader variety of nonmalignant diseases.
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影响因子：
12.4
作者：
Chakravarty R;Goel S;Cai W
通讯作者：
Cai W
影响因子：
4.6
作者：
Balhuizen A;Massa S;Mathijs I;Turatsinze JV;De Vos J;Demine S;Xavier C;Villate O;Millard I;Egrise D;Capito C;Scharfmann R;In't Veld P;Marchetti P;Muyldermans S;Goldman S;Lahoutte T;Bouwens L;Eizirik DL;Devoogdt N
通讯作者：
Devoogdt N
癌症免疫治疗的无创成像。
影响因子：
--
作者：
Abousaway O;Rakhshandehroo T;Van den Abbeele AD;Kircher MF;Rashidian M
通讯作者：
Rashidian M
影响因子：
8.2
作者：
Andralojc, K.;Srinivas, M.;Brom, M.;Joosten, L.;de Vries, I. J. M.;Eizirik, D. L.;Boerman, O. C.;Meda, P.;Gotthardt, M.
通讯作者：
Gotthardt, M.
影响因子：
20.1
作者：
Broisat, Alexis;Hernot, Sophie;Devoogdt, Nick
通讯作者：
Devoogdt, Nick