Estimating enrichment of repetitive elements from high-throughput sequence data.
Estimating enrichment of repetitive elements from high-throughput sequence data.
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DOI:
10.1186/gb-2010-11-6-r69
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发表时间:
2010
期刊:
影响因子:
12.3
通讯作者:
Kharchenko PV
中科院分区:
文献类型:
--
作者:
Day DS;Luquette LJ;Park PJ;Kharchenko PV
We describe computational methods for analysis of repetitive elements from short-read sequencing data, and apply them to study histone modifications associated with the repetitive elements in human and mouse cells. Our results demonstrate that while accurate enrichment estimates can be obtained for individual repeat types and small sets of repeat instances, there are distinct combinatorial patterns of chromatin marks associated with major annotated repeat families, including H3K27me3/H3K9me3 differences among the endogenous retroviral element classes.
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