Dual-function theranostic nanoparticles for drug delivery and medical imaging contrast: perspectives and challenges for use in lung diseases.
Dual-function theranostic nanoparticles for drug delivery and medical imaging contrast: perspectives and challenges for use in lung diseases.
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DOI：
10.1007/s13346-013-0132-4
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发表时间：
2013-08-01
影响因子：
5.4
通讯作者：
Mohapatra, S.
中科院分区：
文献类型：
--
作者：
Howell, M.;Wang, C.;Mahmoud, A.;Hellermann, G.;Mohapatra, S. S.;Mohapatra, S.
具有治疗和成像能力的治疗诊断纳米颗粒有望彻底改变诊断，治疗和预后。早期和准确的检测沿着快速治疗是成功治疗任何疾病的最重要步骤。在过去的十年中，已经创建了各种基于纳米技术的平台，希望改善各种疾病的治疗和诊断。然而，在治疗诊断纳米颗粒能够为慢性呼吸道疾病带来临床解决方案之前，仍然存在重大障碍。一些基本问题，如长期毒性，准确理解这些颗粒的积累，降解和清除，以及这些纳米颗粒的基本理化性质与其体内行为之间的相关性，必须充分了解它们才能用于临床。迄今为止，很少有治疗诊断纳米颗粒研究集中在慢性呼吸道疾病的治疗和诊断上。结合这些治疗诊断纳米颗粒的纳米医学方法可能会转化为临床进展，以改善这些慢性呼吸道疾病的诊断和治疗，并提高患者的生活质量。
Theranostic nanoparticles with both therapeutic and imaging abilities have the promise to revolutionize diagnosis, therapy, and prognosis. Early and accurate detection along with swift treatment are the most important steps in the successful treatment of any disease. Over the last decade, a variety of nanotechnology-based platforms have been created in the hope of improving the treatment and diagnosis of a wide variety of diseases. However, significant hurdles still remain before theranostic nanoparticles can bring clinical solutions to the fight against chronic respiratory diseases. Some fundamental issues such as long-term toxicity, a precise understanding of the accumulation, degradation and clearance of these particles, and the correlation between basic physicochemical properties of these nanoparticles and their in vivo behavior have to be fully understood before they can be used clinically. To date, very little theranostic nanoparticle research has focused on the treatment and diagnosis of chronic respiratory illnesses. Nanomedicine approaches incorporating these theranostic nanoparticles could potentially be translated into clinical advances to improve diagnosis and treatment of these chronic respiratory diseases and enhance quality of life for the patients.
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