An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing.
An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing.
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DOI：
10.1016/j.bioactmat.2021.04.040
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发表时间：
2021-12
影响因子：
18.9
通讯作者：
Zhang XQ
中科院分区：
文献类型：
--
作者：
Hu B;Gao M;Boakye-Yiadom KO;Ho W;Yu W;Xu X;Zhang XQ
长期的、强烈的炎症和过度的氧化应激阻碍糖尿病伤口正常愈合，导致下游疾病，包括上皮再形成和细胞外基质（ECM）形成的延迟。在此，我们报告了一种透明质酸（HA）和壳聚糖为基础的水凝胶（OHA-CMC）具有固有的抗菌和止血活性，通过希夫碱反应制备。通过将纳米技术修饰的姜黄素（CNP）和表皮生长因子（EGF）封装到水凝胶中，OHA-CMC/CNP/EGF在体外表现出非凡的抗氧化、抗炎和促进迁移作用。同时，OHA-CMC/CNP/EGF复合材料呈现与创面愈合同步的按需释药。具体而言，姜黄素在伤口愈合的早期阶段快速且持续地释放以减轻炎症和氧化应激，而EGF的更渐进和持续释放支持晚期增殖和ECM重塑。在糖尿病全层皮肤缺损模型中，OHA-CMC/CNP/EGF显著改善了伤口愈合，具有理想的上皮再形成、肉芽组织形成和皮肤附件再生，突出了这种生物材料作为糖尿病伤口敷料的巨大治疗潜力。OHA-CMC水凝胶显示出优异的固有抗菌和止血活性。OHA-CMC共同提供姜黄素和EGF，并按需释放药物，满足每个愈合阶段的修复要求。OHA-CMC/CNP/EGF具有较强的抗氧化和抗炎活性，并能促进细胞迁移。OHA-CMC/CNP/EGF明显促进糖尿病创面愈合。
Prolonged, intense inflammation and excessive oxidative stress hinder diabetic wounds from healing normally, leading to disorders downstream including the postponement of re-epithelialization and extracellular matrix (ECM) formation. Herein, we report a hyaluronic acid (HA) and chitosan based hydrogel (OHA-CMC) with inherent antibacterial and hemostatic activities fabricated via Schiff base reaction. By encapsulating nanotechnologically-modified curcumin (CNP) and epidermal growth factor (EGF) into the hydrogel, OHA-CMC/CNP/EGF exhibited extraordinary antioxidant, anti-inflammatory, and migration-promoting effects in vitro. Meanwhile, OHA-CMC/CNP/EGF presented on-demand drug release in synchrony with the phases of the wound healing process. Specifically, curcumin was rapidly and constantly released to alleviate inflammation and oxidative stress in the early phase of wound healing, while a more gradual and sustained release of EGF supported late proliferation and ECM remodeling. In a diabetic full-thickness skin defect model, OHA-CMC/CNP/EGF dramatically improved wound healing with ideal re-epithelialization, granulation tissue formation, and skin appendage regeneration, highlighting the enormous therapeutic potential this biomaterial holds as a diabetic wound dressing. OHA-CMC hydrogel showed excellent inherent antibacterial and hemostatic activities. OHA-CMC co-delivered curcumin and EGF with on-demand drug release that met the repair requirements of each healing stage. OHA-CMC/CNP/EGF showed potent antioxidant and anti-inflammation activities, and was capable of promoting cell migration. OHA-CMC/CNP/EGF significantly accelerated diabetic wound healing.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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