Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses.
Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses.
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同时应用超声波脉冲和纳秒激光脉冲去除脉络膜血管
DOI：
10.1038/s41598-018-31045-w
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发表时间：
2018-08-27
影响因子：
4.6
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Zhang H;Xie X;Li J;Qin Y;Zhang W;Cheng Q;Yuan S;Liu Q;Paulus YM;Wang X;Yang X
病理性微血管在导致死亡和主要器官损害的无数疾病中起着至关重要的作用。临床上的一个主要挑战是开发选择性疗法，在不损害周围组织的情况下移除这些病变的微血管。这份报告描述了我们开发的新型光中介超声治疗(PUT)技术，用于精确地移除眼睛中的脉络膜血管。PUT通过同时应用纳秒激光脉冲和超声波脉冲来选择性地移除微血管。在兔眼的体内实验中，我们对视网膜脉络膜表面施加55-75 mJ/cm2的532 nm的光通量和0.5 Mpa的超声压力，频率为0.5 MHz。PUT导致脉络膜层血液灌注量显著减少，持续四周，没有造成侧枝组织损伤，表明PUT能够安全有效地清除脉络膜微血管。PUT凭借其独特的优势，在临床治疗与微血管和新生血管相关的眼部疾病方面具有潜力。
Pathologic microvasculature plays a crucial role in innumerable diseases causing death and major organ impairment. A major clinical challenge is the development of selective therapies to remove these diseased microvessels without damaging surrounding tissue. This report describes our development of novel photo-mediated ultrasound therapy (PUT) technology for precisely removing choroidal blood vessels in the eye. PUT selectively removes microvessels by concurrently applying nanosecond laser pulses with ultrasound bursts. In PUT experiments on rabbit eyesin vivo, we applied 55–75 mJ/cm2of light fluence at the retinochoroidal surface at 532-nm and 0.5 MPa of ultrasound pressure at 0.5 MHz. PUT resulted in significantly reduced blood perfusion in the choroidal layer which persisted to four weeks without causing collateral tissue damage, demonstrating that PUT is capable of removing choroidal microvasculature safely and effectively. With its unique advantages, PUT holds potential for the clinical management of eye diseases associated with microvessels and neovascularization.
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影响因子：
2.9
作者：
Wood, AKW;Ansaloni, S;Sehgal, CM
通讯作者：
Sehgal, CM
DOI：
10.1115/1.3153310
发表时间：
2009-07-01
影响因子：
1.7
作者：
Mukundakrishnan, K.;Ayyaswamy, P. S.;Eckmann, D. M.
通讯作者：
Eckmann, D. M.
影响因子：
2.9
作者：
Church, CC
通讯作者：
Church, CC
叠氮化铵的高压同步辐射X射线衍射和拉曼散射研究
影响因子：
4
作者：
Wu, Xiaoxin;Cui, Hang;Cui, Qiliang
通讯作者：
Cui, Qiliang
影响因子：
4.6
作者：
Hu Z;Zhang H;Mordovanakis A;Paulus YM;Liu Q;Wang X;Yang X
通讯作者：
Yang X