Adult neurogenesis and the olfactory system.
Adult neurogenesis and the olfactory system.
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DOI：
10.1016/j.pneurobio.2009.07.003
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发表时间：
2009-10
影响因子：
6.7
通讯作者：
Greer CA
中科院分区：
文献类型：
--
作者：
Whitman MC;Greer CA
虽然最初在20世纪60年代早期被描述，但直到最近十年，持续成人神经发生的概念才得到广泛接受。来自脑室下区（SVZ）的神经母细胞沿着吻侧迁移流（RMS）迁移到嗅球，在那里它们分化成中间神经元。海马形成亚颗粒带（SGZ）的神经母细胞表现出相对较少的迁移行为，并分化为齿状回颗粒细胞。与胚胎和围产期发育形成鲜明对比的是，这些新分化的神经元必须整合成一个功能完整的回路，而不干扰正在进行的表现。在此，我们简要回顾了嗅觉电路的历史和介绍，回顾了神经干细胞生物学的最新进展，RMS和嗅球的迁移机制，新神经元的分化和存活，最后是突触整合机制。我们的主要重点是嗅觉系统，但我们也将那里发生的事件与海马体形成的事件进行了对比。尽管SVZ和SGZ神经发生都与某些类型的学习有关，但它们的全部功能意义尚不清楚。由于这两种系统都提供了整合新神经母细胞的模型，因此人们对使用神经干细胞来替代因损伤或疾病而丢失的神经元产生了极大的兴趣。尽管许多问题仍未得到解答，但每天都有关于成人神经发生、调节机制和后代命运的新见解出现。我们在这里讨论了这些进展的一些主要特征，并对未来的研究方向进行了推测。
Though initially described in the early 1960s, it is only within the past decade that the concept of continuing adult neurogenesis has gained widespread acceptance. Neuroblasts from the subventricular zone (SVZ) migrate along the rostral migratory stream (RMS) into the olfactory bulb, where they differentiate into interneurons. Neuroblasts from the subgranular zone (SGZ) of the hippocampal formation show relatively little migratory behavior, and differentiate into dentate gyrus granule cells. In sharp contrast to embryonic and perinatal development, these newly differentiated neurons must integrate into a fully functional circuit, without disrupting ongoing performance. Here, after a brief historical overview and introduction to olfactory circuitry, we review recent advances in the biology of neural stem cells, mechanisms of migration in the RMS and olfactory bulb, differentiation and survival of new neurons, and finally mechanisms of synaptic integration. Our primary focus is on the olfactory system, but we also contrast the events occurring there with those in the hippocampal formation. Although both SVZ and SGZ neurogenesis are involved in some types of learning, their full functional significance remains unclear. Since both systems offer models of integration of new neuroblasts, there is immense interest in using neural stem cells to replace neurons lost in injury or disease. Though many questions remain unanswered, new insights appear daily about adult neurogenesis, regulatory mechanisms, and the fates of the progeny. We discuss here some of the central features of these advances, as well as speculate on future research directions.
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DOI：
10.1016/j.devbrainres.2004.03.021
发表时间：
2004-07-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bédard, A;Parent, A
通讯作者：
Parent, A
影响因子：
5.3
作者：
Bovetti, Serena;Hsieh, Yi-Chun;Puche, Adam C.
通讯作者：
Puche, Adam C.
影响因子：
5.3
作者：
Brill, Monika S.;Snapyan, Marina;Goetz, Magdalena
通讯作者：
Goetz, Magdalena
影响因子：
64.8
作者：
Belluscio, L;Lodovichi, C;Katz, LC
通讯作者：
Katz, LC
影响因子：
5.3
作者：
Batista-Brito, Renata;Close, Jennie;Fishell, Gord
通讯作者：
Fishell, Gord