Improved Hemocompatibility on Superhemophobic Micro-Nano-Structured Titanium Surfaces.
Improved Hemocompatibility on Superhemophobic Micro-Nano-Structured Titanium Surfaces.
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DOI：
10.3390/bioengineering10010043
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发表时间：
2022-12-29
影响因子：
4.6
通讯作者：
Popat, Ketul C.
中科院分区：
文献类型：
--
作者：
Manivasagam, Vignesh K.;Popat, Ketul C.
关键词：
血管内支架和心脏瓣膜外壳等与血液接触的钛基植入物由于表面水平的不当相互作用而容易发生血液凝固。作为补充，目前对心血管植入物的临床需求正处于一个新的顶点。因此，制造具有最佳机械性能和改善的血液相容性的植入物，同时与细胞和其他微生物因子进行差异性相互作用是至关重要的。本研究旨在开发一种具有新型微纳米形貌的超疏水植入物表面，使用一种简单的热化学过程。在不同的表面上表征表面形貌、表观接触角和晶体结构。通过评价溶血、纤维蛋白原吸附、细胞粘附和识别、凝血酶生成、补体激活和全血凝血动力学，评估不同表面上的血液/血液相容性。结果表明，超血液/疏水微纳米钛表面通过显著降低纤维蛋白原吸附、血小板粘附和白细胞粘附来改善血液相容性。因此，显影的表面具有用作植入物的高潜力。进一步的研究是针对分析的机制，导致改善的血液相容性的微/纳米表面功能在动态的体外和体内条件下。
Blood-contacting titanium-based implants such as endovascular stents and heart valve casings are prone to blood clotting due to improper interactions at the surface level. In complement, the current clinical demand for cardiovascular implants is at a new apex. Hence, there is a crucial necessity to fabricate an implant with optimal mechanical properties and improved blood compatibility, while simultaneously interacting differentially with cells and other microbial agents. The present study intends to develop a superhydrophobic implant surface with the novel micro–nano topography, developed using a facile thermochemical process. The surface topography, apparent contact angle, and crystal structure are characterized on different surfaces. The hemo/blood compatibility on different surfaces is assessed by evaluating hemolysis, fibrinogen adsorption, cell adhesion and identification, thrombin generation, complement activation, and whole blood clotting kinetics. The results indicate that the super-hemo/hydrophobic micro–nano titanium surface improved hemocompatibility by significantly reducing fibrinogen adsorption, platelet adhesion, and leukocyte adhesion. Thus, the developed surface has high potential to be used as an implant. Further studies are directed towards analyzing the mechanisms causing the improved hemocompatibility of micro/nano surface features under dynamic in vitro and in vivo conditions.
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影响因子：
5
作者：
Manivasagam VK;Sabino RM;Kantam P;Popat KC
通讯作者：
Popat KC
DOI：
10.1016/j.msec.2021.112315
发表时间：
2021-09
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
Manivasagam VK;Popat KC
通讯作者：
Popat KC
影响因子：
3.8
作者：
Lieber, BB;Stancampiano, AP;Wakhloo, AK
通讯作者：
Wakhloo, AK
影响因子：
4.9
作者：
Manivasagam, Vignesh K.;Perumal, Gopinath;Popat, Ketul C.
通讯作者：
Popat, Ketul C.
影响因子：
9.7
作者：
Franco, Albina R.;Fernandes, Emanuel M.;Reis, Rui L.
通讯作者：
Reis, Rui L.