Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells.
Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells.
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DOI：
10.1016/j.msec.2021.112315
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Popat KC
中科院分区：
文献类型：
--
作者：
Manivasagam VK;Popat KC
种植体表面对提高种植体骨整合和延长种植体寿命起着至关重要的作用。当植入物与骨组织接触时，骨髓间充质细胞与植入物表面相互作用，其表面的形态学、润湿性、力学性质和化学性质影响细胞的迁移、增殖和分化。不同的表面改性策略，如陶瓷涂层、表面合金化和表面形貌改性，以改善骨整合已被研究。然而，研究尚未确定哪一种表面性质的影响更大。本研究分别用氢氧化钠和硫酸对钛表面进行水热处理。这种处理导致了两种独特的纳米级表面形貌的发展。这些改性表面的表面形貌，润湿性，化学性质和结晶度表征。细胞毒性，细胞粘附，增殖，形态，以及脂肪干细胞在修饰表面的分化进行了研究。结果表明，润湿性确实影响细胞的初始粘附。然而，表面形态在细胞的扩散、增殖和分化中起着重要的作用。结果表明，用氢氧化钠水热处理的钛表面导致纳米孔结构，促进细胞与表面的适当相互作用，促进成骨细胞谱系。
Implant surface plays a crucial role in improving osseointegration and long-term implant life. When the implant comes in contact with the bone tissue, the bone marrow mesenchymal cells interact with the implant surface and the surface properties such as morphology, wettability, mechanical properties and chemistry influences cell migration, proliferation and differentiation. Different surface modification strategies such as ceramic coatings, surface dealloying, and surface topography modifications for improving osteointegration have been investigated. However, studies have not yet established which of the surface property is more influential. In this study, titanium surfaces were treated hydrothermally with sodium hydroxide and sulfuric acid separately. This treatment led to the development of two unique surface topography at nanoscale. These modified surfaces were characterized for surface morphology, wettability, chemistry, and crystallinity. Cytotoxicity, cell adhesion, proliferation, morphology, and differentiation of adipose derived stem cells on modified surfaces was investigated. The results indicate that wettability does influence initial cell adhesion. However, the surface morphology can play major role in cell spreading, proliferation and differentiation. The results indicate that titanium surfaces treated hydrothermally with sodium hydroxide led to a nanoporous architecture that promoted appropriate cell interaction with the surface promoting osteoblastic lineage.
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影响因子：
--
作者：
Florencio-Silva R;Sasso GR;Sasso-Cerri E;Simões MJ;Cerri PS
通讯作者：
Cerri PS
DOI：
10.1016/j.msec.2019.109850
发表时间：
2019-10-01
影响因子：
7.9
作者：
Dias-Netipanyj, Marcela Ferreira;Cowden, Kari;Soares, Paulo
通讯作者：
Soares, Paulo
影响因子：
3.3
作者：
Kolen'ko, YV;Kovnir, KA;Yoshimura, M
通讯作者：
Yoshimura, M
DOI：
10.1007/s40883-019-00091-9
发表时间：
2019-12-01
影响因子：
2.6
作者：
Cowden, Kari;Dias-Netipanyj, Marcela Ferreira;Popat, Ketul C.
通讯作者：
Popat, Ketul C.
影响因子：
8
作者：
Gongadze E;Kabaso D;Bauer S;Slivnik T;Schmuki P;van Rienen U;Iglič A
通讯作者：
Iglič A