Surface passivation of carbon nanoparticles with branched macromolecules influences near infrared bioimaging.
Surface passivation of carbon nanoparticles with branched macromolecules influences near infrared bioimaging.
复制标题
具有支链大分子的碳纳米粒子的表面钝化影响近红外生物成像。
作者：
Wu L;Luderer M;Yang X;Swain C;Zhang H;Nelson K;Stacy AJ;Shen B;Lanza GM;Pan D
在这项工作中揭示了一种优越的、商业上可开发的“绿色合成”的光活性碳纳米颗粒（OCN）。裸碳颗粒（<20 nm）来自商业食品级蜂蜜。利用超支化聚合物进行表面钝化后，这些粒子的荧光性能得到了显著提高。与线性聚合物（PEG）涂层的碳纳米颗粒相比，近红外发射显著增加。有趣的是，随着钝化剂变得更广泛的分支（伪第2代至第4代），平均辐射效率大大增加，这是光钝化可用表面积增加的直接结果。在体外内皮细胞的存在下，这些颗粒显示出可忽略不计的细胞活力损失。初步体内实验显示，小鼠模型辅助淋巴结有高对比度增强。这些颗粒的异常快速淋巴运输表明，这种方法可能提供更大的方便和减少手术费用，以及提高手术优势，因为患者被安置在手术台上，更容易切除。
A superior and commercially exploitable 'green synthesis' of optically active carbon nanoparticle (OCN) is revealed in this work. The naked carbon particles (<20 nm) were derived from commercial food grade honey. The fluorescence properties of these particles were significantly enhanced by utilizing hyberbranched polymer for surface passivation. A dramatic increase in near infrared emission was achieved compared to a linear polymer (PEG) coated carbon nanoparticles. Interestingly, as passivating agent becomes more extensively branched (pseudo generation 2 to 4), the average radiant efficiency amplifies considerably as a direct result of the increasing surface area available for light passivation. The particles showed negligible loss of cell viability in presence of endothelial cells in vitro. Preliminary in vivo experiment showed high contrast enhancement in auxiliary lymphnode in a mouse model. The exceptionally rapid lymphatic transport of these particles suggests that such an approach may offer greater convenience and reduced procedural expense, as well as improved surgical advantage as the patient is positioned on the table for easier resection.
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影响因子：
4.6
作者：
Bhunia, Susanta Kumar;Saha, Arindam;Maity, Amit Ranjan;Ray, Sekhar C.;Jana, Nikhil R.
通讯作者：
Jana, Nikhil R.
影响因子：
4.3
作者：
Wang, Zhijiang;Wu, Lina;Cai, Wei
通讯作者：
Cai, Wei
蜂蜜碳纳米粒子的绿色合成及其在实时光声成像中的应用
影响因子：
9.9
作者：
Wu, Lina;Cai, Xin;Pan, Dipanjan
通讯作者：
Pan, Dipanjan
通过蔗糖碳化高产率控制合成绿色和蓝色发光碳纳米颗粒
影响因子：
3.3
作者：
Zhang, Jingchun;Shen, Wenqing;Wu, Minghong
通讯作者：
Wu, Minghong
影响因子：
6.7
作者：
Hui, Junfeng;Zhang, Xiaoyong;Wang, Xun
通讯作者：
Wang, Xun