Electrocardiography on admission is associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis.
Electrocardiography on admission is associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis.
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DOI：
10.1002/joa3.12573
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发表时间：
2021-08
影响因子：
2
通讯作者：
Azmi Y
中科院分区：
文献类型：
--
作者：
Alsagaff MY;Oktaviono YH;Dharmadjati BB;Lefi A;Al-Farabi MJ;Gandi P;Marsudi BA;Azmi Y
心电图（ECG）是一种广泛使用的诊断工具，可以在入院时轻松获取，并可以减少与2019冠状病毒病（COVID-19）患者的过度接触。进行了一项系统性综述和Meta分析，以评估入院时ECG与COVID-19不良结局相关的最新证据。对在线数据库进行了文献检索，以获得评价ECG参数和复合不良结局（包括COVID-19患者的ICU入院、重症和死亡率）的观察性研究。来自7项研究的2,539例患者被纳入本分析。汇总分析显示，校正QT（QTc）间期较长和QTc间期延长频率较高与复合不良结局相关（分别为[WMD 6.04 [2.62 - 9.45]，P = 0.001; I 2：0%]和[RR 1.89 [1.52 - 2.36]，P <0.001; I 2：17%]）。与结局良好的患者相比，结局不良的患者的QRS持续时间更长，心率更快（分别为[WMD 2.03 [0.20 - 3.87]，P = 0.030; I 2：46.1%]和[WMD 5.96 [0.96 - 10.95]，P = 0.019; I 2：55.9%]）。预后差的患者左束支分支传导阻滞（LBBB）、房性早搏（PAC）和室性早搏（PVC）的发生率较高（分别为[RR 2.55 [1.19 - 5.47]，P = 0.016; I 2：65.9%]; [RR 1.94 [1.32 - 2.86]，P = 0.001; I 2：62.8%]和[RR 1.84 [1.075 - 3.17]，P = 0.026; I 2：70.6%]）。T波倒置和ST段压低在预后不良的患者中更常见（分别为[RR 1.68 [1.31 - 2.15]，P < .001; I 2：14.3%]和[RR 1.61 [1.31 - 2.00]，P < .001; I 2：49.5%]）。入院时的大多数ECG异常与COVID-19患者的复合不良结局增加显著相关。入院时心电图异常，包括QTc间期延长和QTc间期延长、QRS持续时间延长、心率加快、存在LBBB、PAC、PVC、T波倒置和ST段压低，与COVID-19患者复合不良结局增加显著相关。
Electrocardiogram (ECG) is a widely accessible diagnostic tool that can easily be obtained on admission and can reduce excessive contact with coronavirus disease 2019 (COVID‐19) patients. A systematic review and meta‐analysis were performed to evaluate the latest evidence on the association of ECG on admission and the poor outcomes in COVID‐19. A literature search was conducted on online databases for observational studies evaluating ECG parameters and composite poor outcomes comprising ICU admission, severe illness, and mortality in COVID‐19 patients. A total of 2,539 patients from seven studies were included in this analysis. Pooled analysis showed that a longer corrected QT (QTc) interval and more frequent prolonged QTc interval were associated with composite poor outcome ([WMD 6.04 [2.62‐9.45], P = .001; I 2:0%] and [RR 1.89 [1.52‐2.36], P < .001; I 2:17%], respectively). Patients with poor outcome had a longer QRS duration and a faster heart rate compared with patients with good outcome ([WMD 2.03 [0.20‐3.87], P = .030; I 2:46.1%] and [WMD 5.96 [0.96‐10.95], P = .019; I 2:55.9%], respectively). The incidence of left bundle branch block (LBBB), premature atrial contraction (PAC), and premature ventricular contraction (PVC) were higher in patients with poor outcome ([RR 2.55 [1.19‐5.47], P = .016; I 2:65.9%]; [RR 1.94 [1.32‐2.86], P = .001; I 2:62.8%]; and [RR 1.84 [1.075‐3.17], P = .026; I 2:70.6%], respectively). T‐wave inversion and ST‐depression were more frequent in patients with poor outcome ([RR 1.68 [1.31‐2.15], P < .001; I 2:14.3%] and [RR 1.61 [1.31‐2.00], P < .001; I 2:49.5%], respectively). Most ECG abnormalities on admission are significantly associated with an increased composite poor outcome in patients with COVID‐19. Electrocardiography abnormalities on admission, including longer QTc interval and prolonged QTc interval, longer QRS duration, a faster heart rate, the presence of LBBB, PAC, PVC, T‐wave inversion, and ST‐depression are significantly associated with an increased composite poor outcome in patients with COVID‐19.
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影响因子：
3.9
作者：
De Vita A;Ravenna SE;Covino M;Lanza O;Franceschi F;Crea F;Lanza GA
通讯作者：
Lanza GA
心室过早复合物与心力衰竭的关系（来自社区的动脉粥样硬化风险[ARIC]研究）。
影响因子：
2.8
作者：
Agarwal, Sunil K.;Simpson, Ross J., Jr.;Rautaharju, Pentti;Alonso, Alvaro;Shahar, Eyal;Massing, Mark;Saba, Samir;Heiss, Gerardo
通讯作者：
Heiss, Gerardo
影响因子：
6.1
作者：
Bertini, Matteo;Ferrari, Roberto;Rapezzi, Claudio
通讯作者：
Rapezzi, Claudio
DOI：
10.1016/j.amjcard.2017.06.007
发表时间：
2017-09-01
期刊：
The American journal of cardiology
影响因子：
--
作者：
O'Neal WT;Kamel H;Judd SE;Safford MM;Vaccarino V;Howard VJ;Howard G;Soliman EZ
通讯作者：
Soliman EZ
影响因子：
6
作者：
Mccullough, S. Andrew;Goyal, Parag;Okin, Peter M.
通讯作者：
Okin, Peter M.