Adipocytes, Innate Immunity and Obesity: A Mini-Review.
Adipocytes, Innate Immunity and Obesity: A Mini-Review.
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脂肪细胞、先天免疫和肥胖：小型回顾。
DOI：
10.3389/fimmu.2021.650768
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发表时间：
2021
影响因子：
7.3
通讯作者：
Hsueh WA
中科院分区：
文献类型：
--
作者：
Blaszczak AM;Jalilvand A;Hsueh WA
脂肪组织（AT）炎症在肥胖及其多种相关并发症中的作用是一个迅速扩大的科学兴趣领域。在过去的30年里，脂肪细胞作为内分泌和免疫细胞的作用已经逐步确立。与巨噬细胞一样，脂肪细胞能够通过分泌脂肪因子和细胞因子;脂质、激素和microRNA的外泌体释放;以及与其他免疫细胞的接触相互作用来连接先天性和适应性免疫系统。AT中的关键先天免疫细胞包括脂肪细胞、巨噬细胞、嗜中性粒细胞和2型先天淋巴样细胞（ILC 2）。先天免疫系统在促进肥胖症脂肪组织炎症中的作用将在本次审查中突出。T细胞和B细胞在AT炎症中也起着重要作用，将在本系列的适应性免疫章节中进行讨论。
The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adipocyte is capable of linking the innate and adaptive immune system through the secretion of adipokines and cytokines; exosome release of lipids, hormones, and microRNAs; and contact interaction with other immune cells. Key innate immune cells in AT include adipocytes, macrophages, neutrophils, and innate lymphoid cells type 2 (ILC2s). The role of the innate immune system in promoting adipose tissue inflammation in obesity will be highlighted in this review. T cells and B cells also play important roles in contributing to AT inflammation and are discussed in this series in the chapter on adaptive immunity.
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影响因子：
29
作者：
Deng T;Lyon CJ;Minze LJ;Lin J;Zou J;Liu JZ;Ren Y;Yin Z;Hamilton DJ;Reardon PR;Sherman V;Wang HY;Phillips KJ;Webb P;Wong ST;Wang RF;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
16.6
作者：
Deng T;Liu J;Deng Y;Minze L;Xiao X;Wright V;Yu R;Li XC;Blaszczak A;Bergin S;DiSilvestro D;Judd R;Bradley D;Caligiuri M;Lyon CJ;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
5.8
作者：
Aron-Wisnewsky, Judith;Tordjman, Joan;Clement, Karine
通讯作者：
Clement, Karine
影响因子：
6
作者：
Chedid, Pia;Hurtado-Nedelec, Margarita;Marie, Jean-Claude
通讯作者：
Marie, Jean-Claude
影响因子：
4.1
作者：
Fjeldborg K;Pedersen SB;Møller HJ;Christiansen T;Bennetzen M;Richelsen B
通讯作者：
Richelsen B