Sleep duration and C-reactive protein: Associations among pregnant and non-pregnant women.
Sleep duration and C-reactive protein: Associations among pregnant and non-pregnant women.
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DOI：
10.1016/j.jri.2018.05.003
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发表时间：
2018-08
影响因子：
3.4
通讯作者：
Spira AP
中科院分区：
文献类型：
--
作者：
Holingue C;Owusu JT;Feder KA;Spira AP
与非孕妇相比，孕妇会经历更多的睡眠障碍和更严重的全身炎症。然而，很少有研究在临床样本中检验了孕妇睡眠与炎症之间的联系。我们在美国女性人群样本中检查了孕妇和非孕妇的睡眠时间是否与 C 反应蛋白 (CRP) 水平（炎症标志物）相关。国家健康和营养检查调查 (NHANES) 的参与者是 2,865 名育龄妇女（20-44 岁），这是一个具有全国代表性的美国人样本。在未经调整的分析中，孕妇和非孕妇中，工作日晚上或工作日睡眠 <5 小时与 CRP 水平升高显着相关；然而，在调整人口统计和健康相关变量（抑郁症状、自评健康状况、体重指数（BMI）、糖尿病）后，睡眠<5小时不再与CRP水平显着相关。在调整睡眠时间、人口统计和健康相关变量后，孕妇的 CRP 水平显着升高。我们的研究结果表明，在调整睡眠时间、人口统计和健康因素后，怀孕与外周 CRP 升高相关。此外，在美国育龄孕妇和非孕妇中，睡眠时间短与较高的 CRP 水平相关，但这种联系可以通过自我评估健康状况、BMI 和糖尿病来解释。需要进一步研究来调查这些人群中其他睡眠参数（例如睡眠碎片化）与 CRP 的联系。
Pregnant women experience more sleep disturbances and greater systemic inflammation than non-pregnant women. However, the few studies that have examined the links between sleep and inflammation in pregnant women have been in clinical samples. We examined whether sleep duration is associated with C-reactive protein (CRP) levels, a marker of inflammation, in pregnant and non-pregnant women in a population-based sample of US women. Participants were 2,865 women of reproductive age (aged 20–44 years) in the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of Americans. Sleeping <5 hours on weeknights or workdays was significantly associated with increased CRP levels among both pregnant and non-pregnant women in unadjusted analyses; however, after adjustment for demographic, and health-related variables (depressive symptoms, self-rated health status, body mass index (BMI), diabetes), sleeping <5 hours was no longer significantly related to CRP levels. Pregnant women had significantly higher CRP levels, after adjusting for sleep duration, demographic, and health-related variables. Our findings suggest that pregnancy is associated with increased peripheral CRP, after adjustment for sleep duration, demographic, and health factors. Further, in both pregnant and non-pregnant U.S. women of reproductive age, short sleep duration is associated with higher CRP levels, but this link is explained by self-rated health, BMI, and diabetes. Further studies are needed to investigate links of other sleep parameters (e.g., sleep fragmentation) with CRP in these populations.
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DOI：
10.4049/jimmunol.1002615
发表时间：
2011-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jagannathan-Bogdan M;McDonnell ME;Shin H;Rehman Q;Hasturk H;Apovian CM;Nikolajczyk BS
通讯作者：
Nikolajczyk BS
影响因子：
9.1
作者：
Mullington, Janet M.;Haack, Monika;Toth, Maria;Serrador, Jorge A.;Meier-Ewert, Hans K.
通讯作者：
Meier-Ewert, Hans K.
影响因子：
7.2
作者：
Facco, Francesca L.;Kramer, Jamie;Grobman, William A.
通讯作者：
Grobman, William A.
影响因子：
5.4
作者：
Micheli, Katerina;Komninos, Ioannis;Chatzi, Leda
通讯作者：
Chatzi, Leda
影响因子：
5.6
作者：
de Souza, L;Benedito-Silva, AA;Calil, HM
通讯作者：
Calil, HM