Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT.
Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT.
复制标题
使用多模态全视野 OCT 在多个空间和时间尺度上探测眼睛的动态过程。
作者：
J. Scholler;V. Mazlin;O. Thouvenin;Kassandra Groux;P. Xiao;J. Sahel;M. Fink;C. Boccara;K. Grieve
我们描述了多模态面部全场光学相干断层扫描的最新技术进展，该技术允许检测眼睛中的慢速和快速动态过程。我们证明，通过结合静态、动态和荧光对比，我们可以实现视网膜和前眼的无标记高分辨率成像，时间分辨率从毫秒到几个小时，使我们能够探测 3D 块体组织内亚细胞尺度的生物活性。我们的设置将大视场的高横向分辨率与每秒数百帧的采集速度结合起来，这使其成为临床应用和生物医学研究的有前途的工具。其非接触式和非破坏性的性质被证明对于长期跟踪体外样品演变和人眼体内成像都有效。
We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our setups combine high lateral resolution over a large field of view with acquisition at several hundreds of frames per second which make it a promising tool for clinical applications and biomedical studies. Its contactless and non-destructive nature is shown to be effective for both following in vitro sample evolution over long periods of time and for imaging of the human eye in vivo.
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人眼的结膜微血管循环的定量评估。
影响因子：
3.1
作者：
Shahidi M;Wanek J;Gaynes B;Wu T
通讯作者：
Wu T
眼表病变的高分辨率眼前节光学相干断层扫描：综述和手册。
影响因子：
0.7
作者：
Venkateswaran,Nandini;Mercado,Carolina;Wall,SarahC;Galor,Anat;Wang,Jianhua;Karp,CarolL
通讯作者：
Karp,CarolL
影响因子：
3.8
作者：
Lee, Jonghwan;Wu, Weicheng;Boas, David A.
通讯作者：
Boas, David A.
影响因子：
3.7
作者：
Manchia M;Adli M;Akula N;Ardau R;Aubry JM;Backlund L;Banzato CE;Baune BT;Bellivier F;Bengesser S;Biernacka JM;Brichant-Petitjean C;Bui E;Calkin CV;Cheng AT;Chillotti C;Cichon S;Clark S;Czerski PM;Dantas C;Zompo MD;Depaulo JR;Detera-Wadleigh SD;Etain B;Falkai P;Frisén L;Frye MA;Fullerton J;Gard S;Garnham J;Goes FS;Grof P;Gruber O;Hashimoto R;Hauser J;Heilbronner U;Hoban R;Hou L;Jamain S;Kahn JP;Kassem L;Kato T;Kelsoe JR;Kittel-Schneider S;Kliwicki S;Kuo PH;Kusumi I;Laje G;Lavebratt C;Leboyer M;Leckband SG;López Jaramillo CA;Maj M;Malafosse A;Martinsson L;Masui T;Mitchell PB;Mondimore F;Monteleone P;Nallet A;Neuner M;Novák T;O'Donovan C;Osby U;Ozaki N;Perlis RH;Pfennig A;Potash JB;Reich-Erkelenz D;Reif A;Reininghaus E;Richardson S;Rouleau GA;Rybakowski JK;Schalling M;Schofield PR;Schubert OK;Schweizer B;Seemüller F;Grigoroiu-Serbanescu M;Severino G;Seymour LR;Slaney C;Smoller JW;Squassina A;Stamm T;Steele J;Stopkova P;Tighe SK;Tortorella A;Turecki G;Wray NR;Wright A;Zandi PP;Zilles D;Bauer M;Rietschel M;McMahon FJ;Schulze TG;Alda M
通讯作者：
Alda M
DOI：
10.1073/pnas.0406877102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Gustafsson, MGL
通讯作者：
Gustafsson, MGL