Dietary energy density is positively associated with breast density among young women.
Dietary energy density is positively associated with breast density among young women.
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DOI：
10.1016/j.jand.2014.08.015
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发表时间：
2015-03
影响因子：
4.8
通讯作者：
Dorgan, Joanne F.
中科院分区：
文献类型：
--
作者：
Jones, Jessica A.;Hartman, Terryl J.;Klifa, Catherine S.;Coffman, Donna L.;Mitchell, Diane C.;Vernarelli, Jacqueline A.;Snetselaar, Linda G.;Van Horn, Linda;Stevens, Victor J.;Robson, Alan M.;Himes, John H.;Shepherd, John A.;Dorgan, Joanne F.
乳房密度是乳腺癌风险的一个既定预测因子，人们对饮食等可改变的生活方式因素与乳房密度的关系非常感兴趣。确定饮食能量密度(ED)是否与年轻女性的百分比致密乳房体积(%DBV)和绝对致密乳房体积(ADBV)相关。对参与儿童饮食干预研究后续研究(DISC06)的妇女进行了横断面分析。用磁共振成像(MRI)测量百分比DBV和ADBV。饮食通过三次24小时召回进行评估。膳食ED(千卡/克)用三种方法计算：(1)仅食物，(2)食物和热量饮料，(3)食物和所有饮料。172名女性(25-29岁)参加了DISC06研究。报告隆胸或缩胸手术的受试者，或在乳房密度评估前三个月内怀孕或哺乳的受试者被排除在外。ADBV和%DBV。采用多变量线性混合效应模型。最终的模型根据种族、吸烟状况、教育程度、产次、性激素使用时间、全身脂肪百分比、儿童BMI z评分和饮料能量进行了调整。调整后，纯食物ED每增加1千卡/克单位，%DBV增加25.9%(95%可信区间=6.2至56.8%)(p=0.01)。儿童期BMI z-Score修正了纯食物ED和%DBV之间的关联，使得只有在儿童时期体重较重的女性中才观察到显著的正关联。在所有女性中，只吃食物的ED与ADBV并不相关，但在儿童时期BMI z得分较高的女性中观察到了边缘显著的正相关。这是第一份表明饮食ED在乳房密度中的潜在作用的报告；长期接触高ED饮食对乳腺癌风险的影响尚不清楚。
Breast density is an established predictor of breast cancer risk, and there is considerable interest in associations of modifiable lifestyle factors, such as diet, with breast density. To determine if dietary energy density (ED) is associated with percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) in young women. A cross-sectional analysis was conducted with women who participated in the Dietary Intervention Study in Children Follow-Up Study (DISC06). %DBV and ADBV were measured by magnetic resonance imaging (MRI). Diet was assessed by three 24-hour recalls. Dietary ED (kcal/g) was calculated using three methods: (1) food only, (2) food and caloric beverages, and (3) food and all beverages. 172 women (25–29 years) who were enrolled in the DISC06 study. Subjects who reported breast augmentation or reduction surgery or were pregnant or lactating within three months before breast density assessment were excluded. ADBV and %DBV. Multivariable linear mixed effects models were used. Final models were adjusted for race, smoking status, education, parity, duration of sex hormone use, whole body percent fat, childhood BMI z-score, and energy from beverages. After adjustment, each 1 kcal/g unit increase in food-only ED was associated with a 25.9% (95% confidence interval = 6.2 to 56.8%) increase in %DBV (p=0.01). Childhood BMI z-score modified the association between food-only ED and %DBV such that a significant positive association was observed only in women who were heavier as children. Food-only ED was not associated with ADBV in all women, but a borderline significant positive association was observed in women who had higher childhood BMI z-scores. This is the first report to suggest a potential role for dietary ED in breast density; the effects of long-term exposure to high ED diets on breast cancer risk remain unknown.
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影响因子：
3.8
作者：
Lope, Virginia;Perez-Gomez, Beatriz;Sanchez-Contador, Carmen;Carmen Santamarina, Maria;Moreo, Pilar;Vidal, Carmen;Soledad Laso, Maria;Ederra, Maria;Pedraz-Pingarron, Carmen;Gonzalez-Roman, Isabel;Garcia-Lopez, Milagros;Salas-Trejo, Dolores;Peris, Merce;Pilar Moreno, Maria;Antonio Vazquez-Carrete, Jose;Collado, Francisca;Aragones, Nuria;Pollan, Marina
通讯作者：
Pollan, Marina
影响因子：
1.9
作者：
Lindgren J;Dorgan J;Savage-Williams J;Coffman D;Hartman T
通讯作者：
Hartman T
影响因子：
3.8
作者：
Martin, Lisa J.;Greenberg, Carolyn V.;Boyd, Norman F.
通讯作者：
Boyd, Norman F.
影响因子：
7.1
作者：
Ledikwe, Jenny H.;Blanck, Heidi M.;Rolls, Barbara J.
通讯作者：
Rolls, Barbara J.
影响因子：
5
作者：
BRISSON, J;VERREAULT, R;MEYER, F
通讯作者：
MEYER, F