Cumulative Sun Exposure and Melanoma in a Population-Based Case-Control Study: Does Sun Sensitivity Matter?
Cumulative Sun Exposure and Melanoma in a Population-Based Case-Control Study: Does Sun Sensitivity Matter?
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DOI：
10.3390/cancers14041008
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发表时间：
2022-02-16
期刊：
影响因子：
5.2
通讯作者：
Dennis LK
中科院分区：
文献类型：
--
作者：
Dennis LK
黑色素瘤已经被清楚地证明与晒伤和其他类型的间歇性日晒有关。至于累积日晒与黑色素瘤的关系，目前还不太清楚。在这项病例对照研究中，每年春季至秋季期间或数十年的累积日照小时数被检查，以估计一生的日照小时数。在60岁之前没有发现与此相关的因素。然而，当按白皙的肤色分层时，我们发现，在白皙皮肤的人中，与日照时间几乎或没有关联，但在中等或深色皮肤的人中，终生暴露于日光下的时间更长的风险增加。皮肤黑色素瘤(CM)一直与间歇性阳光暴晒有关，而与慢性阳光暴晒的相关性则存在争议。这项研究的目的是基于这些因素可能如何关联的理论概念来检查CM、太阳敏感度和太阳曝光量之间的复杂关系。在美国爱荷华州一项基于人群的黑色素瘤病例对照研究中，收集了生命周期中详细的日照暴露史和日光敏感度的各种测量。参与者被问及在每年3月至10月期间，他们在不同时期或数十年内每天的日照时间，以估计一生中累积的日照小时数。除了晒伤的倾向外，大多数标准的日光敏感度测量都显示CM的优势比(OR)增加。生命早期的总日照时数与此有极小的关联。然而，白皙的肤色和终生的日照时间之间存在交互作用，在中等肤色和深色皮肤的参与者中，CM的相关性最强。这表明，高水平的累积阳光暴露可能会增加对阳光不敏感的人的CM，通常情况下，CM的风险较低。这一发现对预防黑色素瘤的努力有一定的意义，这与皮肤较黑的人在阳光下的时间有关。
Melanoma has been clearly shown to be related to sunburns and other types of intermittent sun exposure. It is less clear how cumulative sun exposure is related to melanoma. In this case–control study, the cumulative hours of sun exposure per day were examined between spring and fall each year over periods or decades of life to estimate lifetime hours of sun exposure. No associations were found before the age of 60. However, when stratified by fair skin color, we found little or no association with hours of sun exposure among fair-skinned individuals, but found an increased risk for higher hours of sun exposure among medium- or darker-skinned individuals for lifetime exposure. Cutaneous melanoma (CM) has consistently been associated with intermittent sun exposure, while the association with chronic sun exposure is debated. The goal of this research was to examine the complex relationship between CM, sun sensitivity and sun exposure based on theoretical concepts of how these factors may be associated. Detailed sun exposure histories across life periods and various measures of sun sensitivity were collected in a population-based case–control study of melanoma in Iowa, USA. Participants were asked about their hours of sun exposure per day between March and October each year over periods or decades of life to estimate cumulative lifetime hours of sun exposure. Increased odds ratios (ORs) for CM were seen for most standard measures of sun sensitivity except for the tendency to sunburn. Minimal associations were seen with total hours of sun exposure early in life. However, an interaction was seen between fair skin color and lifetime hours of sun exposure, where the strongest associations with CM were seen among medium-skinned and dark-skinned participants. This suggests that cumulative sun exposure at high levels may increase CM among non-sun-sensitive individuals typically at lower risk of CM. Such a finding has implications for the prevention effort for melanoma regarding time in the sun among darker-skinned individuals.
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影响因子：
10.3
作者：
Lasithiotakis, K.;Leiter, U.;Garbe, C.
通讯作者：
Garbe, C.
DOI：
10.1111/jdv.12488
发表时间：
2015-01-01
影响因子：
9.2
作者：
Kaskel, P.;Lange, U.;Kron, M.
通讯作者：
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影响因子：
5.6
作者：
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通讯作者：
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影响因子：
8.8
作者：
ELWOOD, JM;WILLIAMSON, C;STAPLETON, PJ
通讯作者：
STAPLETON, PJ
影响因子：
2.3
作者：
GREEN, A
通讯作者：
GREEN, A