Role of vitamin D and calcium signaling in epidermal wound healing.
Role of vitamin D and calcium signaling in epidermal wound healing.
复制标题
DOI：
10.1007/s40618-022-01893-5
复制
发表时间：
2023-02
影响因子：
5.4
通讯作者：
Bikle, D. D.
中科院分区：
文献类型：
--
作者：
Bikle, D. D.
这篇综述将讨论维生素D和钙信号在表皮创伤反应中的作用，特别关注表皮和毛囊的干细胞，有助于创伤反应。选择出版物有关的伤口愈合的机制一般和钙和维生素D在伤口愈合中的作用，特别是审查。在受伤后，毛囊和毛囊间表皮的干细胞被激活以增殖并迁移到伤口，在那里它们承担表皮命运以使伤口再上皮化并再生表皮。维生素D和钙敏感受体（分别为VDR和CaSR）在毛囊和表皮的干细胞中表达，在那里它们在使干细胞对创伤作出反应方面起关键作用。从这些细胞中缺失Vdr和/或Casr会延迟伤口愈合。VDR受共调节因子如Med 1复合物和其他转录因子如Ctnnb（β-连环蛋白）和p63调节。由维生素D和钙共同刺激的Cdh 1/Ctnn（E-cadherin/catenin）复合物的形成在活化、迁移和再上皮化过程中起着关键作用。维生素D和钙信号对于表皮和毛囊干细胞对创伤做出反应的能力至关重要。伴随钙信号传导减少的维生素D缺乏可导致延迟和/或慢性伤口，这是发病、生产力损失和医疗费用的主要原因。
This review will discuss the role of vitamin D and calcium signaling in the epidermal wound response with particular focus on the stem cells of the epidermis and hair follicle that contribute to the wounding response. Selected publications relevant to the mechanisms of wound healing in general and the roles of calcium and vitamin D in wound healing in particular were reviewed. Following wounding the stem cells of the hair follicle and interfollicular epidermis are activated to proliferate and migrate to the wound where they take on an epidermal fate to re-epithelialize the wound and regenerate the epidermis. The vitamin D and calcium sensing receptors (VDR and CaSR, respectively) are expressed in the stem cells of the hair follicle and epidermis where they play a critical role in enabling the stem cells to respond to wounding. Deletion of Vdr and/or Casr from these cells delays wound healing. The VDR is regulated by co-regulators such as the Med 1 complex and other transcription factors such as Ctnnb (beta-catenin) and p63. The formation of the Cdh1/Ctnn (E-cadherin/catenin) complex jointly stimulated by vitamin D and calcium plays a critical role in the activation, migration, and re-epithelialization processes. Vitamin D and calcium signaling are critical for the ability of epidermal and hair follicle stem cells to respond to wounding. Vitamin D deficiency with the accompanying decrease in calcium signaling can result in delayed and/or chronic wounds, a major cause of morbidity, loss of productivity, and medical expense.
登录
查看更多内容
影响因子：
3
作者：
Behne, Martin J.;Sanchez, Susana;Gratton, Enrico
通讯作者：
Gratton, Enrico
影响因子：
4.9
作者：
Choi, Sehee;Yoon, Minguen;Choi, Kang-Yell
通讯作者：
Choi, Kang-Yell
影响因子：
15.9
作者：
GRZESIAK, JJ;PIERSCHBACHER, MD
通讯作者：
PIERSCHBACHER, MD
影响因子：
6.5
作者：
Langton, Abigail K.;Herrick, Sarah E.;Headon, Denis J.
通讯作者：
Headon, Denis J.
影响因子：
1.4
作者：
Brenner, Maria;Hilliard, Carol;O'Callaghan, Gill
通讯作者：
O'Callaghan, Gill