Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
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DOI：
10.1371/journal.pone.0102995
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Barkhof F
中科院分区：
文献类型：
--
作者：
Adriaanse SM;Binnewijzend MA;Ossenkoppele R;Tijms BM;van der Flier WM;Koene T;Smits LL;Wink AM;Scheltens P;van Berckel BN;Barkhof F
早发性阿尔茨海默病（AD）患者呈现出与晚发性AD患者不同的临床特征。这可以部分解释为皮质萎缩，虽然大脑组织可能提供更多的见解。本研究的目的是检查早发性和晚发性AD患者的功能连接。20例早发性（<65岁）、28例晚发性（≥ 65岁）AD患者以及15例“年轻”（<65岁）和31例“老年”（≥65岁）年龄匹配对照的静息状态fMRI扫描可用。静息状态网络掩码用于创建特定主题的映射。组间差异进行了检查，使用非参数排列检验，占灰质。在五个认知领域的表现与AD患者的功能连接进行相关性分析。当比较两个对照组（年轻对照组与老年对照组）时，任何RSN中的功能连接性均无差异，这意味着衰老对功能连接性无一般影响。与年龄匹配的对照组相比，早发性AD的功能连接在所有网络中均较低，晚发性AD在默认模式网络中显示出较低的功能连接。早发性AD的听觉、感觉运动、背视系统和默认模式网络的功能连接性低于晚发性AD。在患者中，默认模式网络的功能连接与视觉结构相关。右背视觉系统的功能连接与患者的注意力相关。仅在晚发性AD患者中，感觉-运动系统的功能连接性较高与记忆表现较差相关。与晚发性AD相比，早发性AD的脑组织功能更广泛地受到破坏。这可能解释了不同的临床特征，尽管需要更多的研究功能连接和认知表现的关系。
Early-onset Alzheimer’s disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onset and late-onset AD patients. Resting-state fMRI scans of 20 early-onset (<65 years old), 28 late-onset (≥65 years old) AD patients and 15 “young” (<65 years old) and 31 “old” (≥65 years old) age-matched controls were available. Resting-state network-masks were used to create subject-specific maps. Group differences were examined using a non-parametric permutation test, accounting for gray-matter. Performance on five cognitive domains were used in a correlation analysis with functional connectivity in AD patients. Functional connectivity was not different in any of the RSNs when comparing the two control groups (young vs. old controls), which implies that there is no general effect of aging on functional connectivity. Functional connectivity in early-onset AD was lower in all networks compared to age-matched controls, where late-onset AD showed lower functional connectivity in the default-mode network. Functional connectivity was lower in early-onset compared to late-onset AD in auditory-, sensory-motor, dorsal-visual systems and the default mode network. Across patients, an association of functional connectivity of the default mode network was found with visuoconstruction. Functional connectivity of the right dorsal visual system was associated with attention across patients. In late-onset AD patients alone, higher functional connectivity of the sensory-motor system was associated with poorer memory performance. Functional brain organization was more widely disrupted in early-onset AD when compared to late-onset AD. This could possibly explain different clinical profiles, although more research into the relationship of functional connectivity and cognitive performance is needed.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
4.8
作者：
Agosta, Federica;Rocca, Maria Assunta;Filippi, Massimo
通讯作者：
Filippi, Massimo
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
4.2
作者：
de Waal, Hanneke;Stam, Cornelis J.;van der Flier, Wiesje M.
通讯作者：
van der Flier, Wiesje M.
影响因子：
4
作者：
Koedam, Esther L. G. E.;Lauffer, Vivian;Pijnenburg, Yolande A. L.
通讯作者：
Pijnenburg, Yolande A. L.