Impacts of Astaxanthin Supplementation on Walking Capacity by Reducing Oxidative Stress in Nursing Home Residents.
Impacts of Astaxanthin Supplementation on Walking Capacity by Reducing Oxidative Stress in Nursing Home Residents.
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DOI：
10.3390/ijerph192013492
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发表时间：
2022-10-18
影响因子：
--
通讯作者：
Fujino, Hidemi
中科院分区：
文献类型：
--
作者：
Nakanishi, Ryosuke;Kanazashi, Miho;Tanaka, Masayuki;Tanaka, Minoru;Fujino, Hidemi
氧化应激与耐力和肌肉力量的退化有关，这些退化大多伴随着衰老。虾青素补充剂具有优异的抗氧化活性，而没有任何促氧化特性。在这项研究中，我们调查了虾青素补充剂如何影响养老院居民的步行耐力和肌肉力量。健康老年人（年龄：67至94岁）被分为两组：13名受试者接受了16周的24 mg日剂量的虾青素（虾青素组），11名受试者接受了安慰剂（安慰剂组）。这些受试者进行了比较，使用身体成分测量，血清d-ROM水平，6分钟步行的距离，6分钟步行试验后的血乳酸水平，和肌肉力量。补充后，与安慰剂组相比，虾青素组的d-ROM和6分钟步行试验后的血乳酸水平显著降低（p < 0.05）。此外，尽管6-MWT后乳酸水平显著降低（p < 0.05），但虾青素组的步行距离显著高于安慰剂组（p < 0.05）。然而，在肌肉质量和力量方面没有观察到显著的组间差异。补充16周的虾青素对提高老年人的耐力是有效的。虾青素补充剂抑制休息时的d-ROM和6分钟步行试验后的乳酸产生。相比之下，虾青素补充剂在肌肉质量和力量方面没有显示出显著的组间差异。因此，这种效果很可能伴随着耐力的增加，而不是肌肉力量的增加。
Oxidative stress is associated with deterioration of endurance and muscle strength, which are mostly accompanied by aging. Astaxanthin supplement has excellent antioxidant activity without any pro-oxidative properties. In this study, we investigated how astaxanthin supplementation affects walking endurance and muscle strength in nursing home residents. Healthy elderly individuals (age: 67 to 94) were divided into two groups: 13 subjects received a daily dose of 24 mg of astaxanthin for 16 weeks (astaxanthin group) and 11 subjects received a placebo (placebo group). These subjects were compared using body component measurements, serum d-ROM levels, the distance of 6-min walking, blood lactate levels after the 6-min walking test, and muscle strength. After supplementation, the levels of d-ROMs and blood lactate after the 6-min walking test in the astaxanthin group significantly decreased compared with the placebo group (p < 0.05). Additionally, the walking distance was significantly higher in the astaxanthin group than in the placebo group (p < 0.05), despite a significant reduction in lactate levels after 6-MWT (p < 0.05). However, no significant intergroup differences were observed in muscle mass and strength. Astaxanthin supplement for 16 weeks is effective to increase the endurance capacity of the elderly. Astaxanthin supplement suppresses d-ROMs at rest and lactic acid production after the 6-min walk test. In contrast, astaxanthin supplement did not show significant intergroup differences in the muscle mass and strength. Therefore, the effect was most likely accompanied by an increase in endurance instead of an increase in muscle strength.
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影响因子：
2.3
作者：
Hogrel, Jean-Yves
通讯作者：
Hogrel, Jean-Yves
影响因子：
2.3
作者：
Finsterer J
通讯作者：
Finsterer J
DOI：
10.1249/01.mss.0000147632.17450.ff
发表时间：
2004-12-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Fatouros, IG;Jamurtas, AZ;Deliconstantinos, G
通讯作者：
Deliconstantinos, G
影响因子：
2.7
作者：
Malek, Moh H.;Olfert, I. Mark
通讯作者：
Olfert, I. Mark
影响因子：
3.3
作者：
Groen, Bart B. L.;Hamer, Henrike M.;van Loon, Luc J. C.
通讯作者：
van Loon, Luc J. C.