Biomarkers of peripheral muscle fatigue during exercise.
Biomarkers of peripheral muscle fatigue during exercise.
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DOI：
10.1186/1471-2474-13-218
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发表时间：
2012-11-08
影响因子：
2.3
通讯作者：
Finsterer J
中科院分区：
文献类型：
--
作者：
Finsterer J
外周肌肉疲劳的生物标志物(BPMF)被用来提供对运动过程中疲劳机制的洞察，以检测异常疲劳或检测代谢途径缺陷。该综述旨在描述有关运动性肌肉疲劳最重要的生物标志物的最新进展和未来展望。BPMF根据与三磷酸腺苷代谢、酸中毒或氧化代谢相关的疲劳机制进行分类。肌肉疲劳也与免疫反应有关。钙处理受损，生物能量途径紊乱，以及遗传反应。免疫和遗传反应可能会使肌肉容易疲劳，但可能不会直接导致肌肉疲劳。BPMF的产生主要取决于运动的类型。BPMF需要随着被监测过程的变化而变化，要稳定，没有明显的日变化，与运动强度有很好的相关性，并以可检测到的量存在于易于接触的生物液中。最广为人知的BPMF是血清乳酸和白介素6。最广泛的临床应用是通过乳酸负荷试验筛查线粒体疾病中的氧化代谢缺陷。然而，大多数其他BPMF的临床相关性仍在争论中，因为它们往往取决于年龄、性别、身体健康、运动时的能量供应、产生BPMF所需的运动类型，以及是否调查健康或患病的受试者。尽管人们对BPMF在疲劳中的作用知之甚少，但在特定的标准化条件下测量BPMF似乎有助于评估运动和疲劳期间的生物状态或过程。
Biomarkers of peripheral muscle fatigue (BPMFs) are used to offer insights into mechanisms of exhaustion during exercise in order to detect abnormal fatigue or to detect defective metabolic pathways. This review aims at describing recent advances and future perspectives concerning the most important biomarkers of muscle fatigue during exercise. BPMFs are classified according to the mechanism of fatigue related to adenosine-triphosphate-metabolism, acidosis, or oxidative-metabolism. Muscle fatigue is also related to an immunological response. impaired calcium handling, disturbances in bioenergetic pathways, and genetic responses. The immunological and genetic response may make the muscle susceptible to fatigue but may not directly cause muscle fatigue. Production of BPMFs is predominantly dependent on the type of exercise. BPMFs need to change as a function of the process being monitored, be stable without appreciable diurnal variations, correlate well with exercise intensity, and be present in detectable amounts in easily accessible biological fluids. The most well-known BPMFs are serum lactate and interleukin-6. The most widely applied clinical application is screening for defective oxidative metabolism in mitochondrial disorders by means of the lactate stress test. The clinical relevance of most other BPMFs, however, is under debate, since they often depend on age, gender, physical fitness, the energy supply during exercise, the type of exercise needed to produce the BPMF, and whether healthy or diseased subjects are investigated. Though the role of BPMFs during fatigue is poorly understood, measuring BPMFs under specific, standardised conditions appears to be helpful for assessing biological states or processes during exercise and fatigue.
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DOI：
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发表时间：
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影响因子：
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