Periconceptional nutrient intakes and risks of neural tube defects in California.
Periconceptional nutrient intakes and risks of neural tube defects in California.
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DOI：
10.1002/bdra.20675
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发表时间：
2010-08
影响因子：
--
通讯作者：
Shaw, Gary M.
中科院分区：
文献类型：
--
作者：
Carmichael, Suzan L.;Yang, Wei;Shaw, Gary M.
本研究调查了加州县叶酸强化后分娩的孕妇，神经管缺陷（NTDs）与围受孕期摄入含叶酸补充剂和膳食营养素（包括叶酸）的关系。这项以人群为基础的病例对照研究包括1999-2003年出生的患有脊柱裂（189例）或无脑畸形（141例）的胎儿和活产婴儿，以及625例无畸形的活产对照。母亲们在电话采访中报告了补充剂的使用情况，其中包括107项食物频率问卷。对于膳食营养素，根据对照分布，比较了<25百分位数、25百分位数-<75百分位数（参考）和≥ 75百分位数的摄入量。校正潜在混杂因素后，任何补充剂摄入与不摄入补充剂相比，无脑畸形和脊柱裂的OR分别为0.8（95% CI 0.5，1.3）和0.8（95% CI 0.6，1.2）。通过母亲摄入维生素补充剂分层后，血糖途径中的大多数因素与NTD无关，除了低水平的果糖和葡萄糖与无脑儿显著相关。一些有助于一碳代谢的营养素显示出降低的风险（叶酸，核黄素，维生素B6和B12）;其他则没有（胆碱，蛋氨酸，锌）。抗氧化营养素往往与降低风险有关（维生素C、E、A、β-胡萝卜素、叶黄素）。母亲的维生素补充剂的摄入量是适度的，如果在所有与NTD的风险降低。饮食中摄入几种有助于一碳代谢和氧化应激的营养素与NTD风险降低相关。
This study investigated the association of neural tube defects (NTDs) with maternal periconceptional intake of folic acid-containing supplements and dietary nutrients, including folate, among deliveries that occurred after folic acid fortification in selected California counties. The population-based case-control study included fetuses and live born infants with spina bifida (189) or anencephaly (141) and 625 nonmalformed, live born controls delivered from 1999–2003. Mothers reported supplement use during telephone interviews, which included a 107-item food frequency questionnaire. For dietary nutrients, intakes <25th, 25th–<75th (reference), and ≥75th percentile were compared, based on control distributions. After adjustment for potential confounders, any versus no supplement intake resulted in ORs of 0.8 (95% CI 0.5, 1.3) for anencephaly and 0.8 (95% CI 0.6, 1.2) for spina bifida. After stratification by maternal intake of vitamin supplements, most factors in the glycemic pathway were not associated with either NTD, with the exception of low levels of fructose and glucose that were significantly associated with anencephaly. Some nutrients that contribute to one-carbon metabolism showed lowered risks (folate, riboflavin, vitamins B6 and B12); others did not (choline, methionine, zinc). Anti-oxidant nutrients tended to be associated with lowered risks (vitamins C, E, A, β-carotene, lutein). Mother’s intake of vitamin supplements was modestly if at all associated with a lowered risk of NTDs. Dietary intake of several nutrients contributing to one-carbon metabolism and oxidative stress were associated with reduced NTD risk.
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影响因子：
158.5
作者：
CZEIZEL, AE;DUDAS, I
通讯作者：
DUDAS, I
DOI：
10.1016/s0002-9378(03)00807-x
发表时间：
2003-12-01
影响因子：
9.8
作者：
Groenen, PM;Peer, PG;Steegers-Theunissen, RP
通讯作者：
Steegers-Theunissen, RP
影响因子：
120.7
作者：
MILUNSKY, A;JICK, H;WILLETT, W
通讯作者：
WILLETT, W
DOI：
10.1002/bdra.20466
发表时间：
2008-08-01
影响因子：
--
作者：
Chen, Brian H.;Carmichael, Suzan L.;Shaw, Gary M.
通讯作者：
Shaw, Gary M.
影响因子：
120.7
作者：
Salmeron, J;Manson, JE;Willett, WC
通讯作者：
Willett, WC