Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan County, China.
Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan County, China.
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DOI：
10.1007/s12250-021-00398-4
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发表时间：
2021-10
影响因子：
5.5
通讯作者：
Liang G
中科院分区：
文献类型：
--
作者：
Wang Q;Fu S;Cheng J;Xu X;Wang J;Wu B;Tian X;Li Y;He Y;Li F;Nie K;Xu S;Wang B;Wang H;Lu X;Liang G
我们从武乡县的野生白蛉中分离到一种白蛉病毒属的新种，命名为武乡病毒（WUXV）。在这项研究中，我们从2019年从中国阳泉县两个村庄收集的野生白蛉中重新分离了WUXV。从鸡圈和羊圈的白蛉标本中分离到4株能引起BHK-21细胞病变的病毒。系统发育分析表明，这4株病毒代表了以前分离的WUXV。从羊圈中分离的病毒的最低感染率（MIR）为3.21，从鸡圈中分离的病毒的MIR为3.45。当地健康人和家鸡血清中武乡病毒中和抗体阳性率分别为8.7%（4/46）和100%（4/4），提示武乡病毒可感染人畜。鉴于武乡病毒对人畜均有传染性，且在我国地理分布较为广泛，加强对武乡病毒在人畜中感染状况的调查研究，具有重要的公共卫生意义。在线版本包含补充材料，可通过10.1007/s12250-021-00398-4获得。
We previously isolated a new species of the genus Phlebovirus from wild sandflies collected from Wuxiang County in central China, which named the Wuxiang virus (WUXV). In this study, we re-isolated the WUXV from wild sandflies collected from two villages in Yangquan County, China in 2019. Four virus isolates that caused cytopathic effects in BHK-21 cells were successfully isolated from sandfly specimens collected from chicken pens and sheep pens. Phylogenetic analyses of the L, M and S gene segments of the viruses revealed that the four virus strains represented the previously isolated WUXV. The minimum infection rate (MIR) of the virus isolated from the sheep pen was 3.21, and the MIR of the virus isolated from the chicken pen was 3.45. The positive rates of Wuxiang virus neutralizing antibodies in serum samples of local healthy people and domestic chickens were 8.7% (4/46) and 100% (4/4), respectively, suggesting that Wuxiang virus can infect human and animal. In view of the fact that Wuxiang virus is infectious to humans and animals and has a relatively wide geographical distribution in China, it is of great public health significance to strengthen the investigation and study on the infection status of Wuxiang virus in humans and animals. The online version contains supplementary material available at 10.1007/s12250-021-00398-4.
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