Suppression and recovery of estrous behavior in Syrian hamsters after changes in metabolic fuel availability.

Suppression and recovery of estrous behavior in Syrian hamsters after changes in metabolic fuel availability.
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代谢燃料可用性变化后叙利亚仓鼠发情行为的抑制和恢复。

DOI:
10.1152/ajpregu.2001.280.5.r1393
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发表时间:
2001
期刊:
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子:
--
通讯作者:
Lubbers,LS
Lubbers,LS
中科院分区:
--
文献类型:
--
作者:
Jones,JE;Lubbers,LS

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可氧化代谢燃料可用性的降低抑制了繁殖。48小时的代谢燃料剥夺抑制卵巢切除的叙利亚仓鼠的发情行为,但对这种抑制的时间过程知之甚少。同样,再进食也能逆转剥夺引起的抑制,但恢复的速度尚未得到检验。在两个实验中,我们测定了:(1)使用代谢抑制剂治疗的仓鼠发情行为下降的速度;(2)禁食48小时后,仓鼠恢复性接受能力的速度。我们还测量了瘦素和胰岛素的循环水平,试图确定它们与抑制和恢复动情行为的关系。抑制前凸需要超过24小时的代谢抑制剂,而仅6小时的再喂养就足以使性接受性恢复到正常水平。血浆胰岛素和瘦素水平与动情行为的变化都不一致。我们得出结论:1)发情行为的抑制比快速恢复后的恢复要慢;2)循环瘦素和胰岛素的变化可能在这些行为变化中没有关键作用。
A reduction in the availability of oxidizable metabolic fuels inhibits reproduction. Forty-eight hours of metabolic fuel deprivation inhibits estrous behavior in ovariectomized, steroid-treated Syrian hamsters, but little is known about the time course of this inhibition. Likewise, refeeding reverses deprivation-induced suppression, but the rate of recovery has not been examined. In two experiments we determined1) the rate at which estrous behavior declines in hamsters treated with metabolic inhibitors and2) how rapidly sexual receptivity is restored when hamsters are refed after a 48-h fast. We also measured circulating levels of leptin and insulin in an attempt to determine their relationship to the inhibition and restoration of estrous behavior. More than 24 h of metabolic inhibitor administration were required to inhibit lordosis, whereas only 6 h of refeeding were sufficient to restore the display of sexual receptivity to normal levels. Neither plasma insulin nor leptin levels paralleled the changes in estrous behavior. We concluded that1) suppression of estrous behavior occurs more slowly than recovery after a fast and2) changes in circulating leptin and insulin probably do not have a critical role in these behavioral changes.
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