Hemispheric asymmetry in new neurons in adulthood is associated with vocal learning and auditory memory.
Hemispheric asymmetry in new neurons in adulthood is associated with vocal learning and auditory memory.
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DOI：
10.1371/journal.pone.0108929
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Vicario DS
中科院分区：
文献类型：
--
作者：
Tsoi SC;Aiya UV;Wasner KD;Phan ML;Pytte CL;Vicario DS
许多大脑区域在结构和功能上表现出横向差异，并且在成年期也会合并新的神经元，这些神经元被认为在学习和新记忆的形成中起作用。然而，新神经元对半球处理差异的贡献尚不清楚。目前的研究结合了细胞、行为和生理方法来解决是否1)新神经元在大脑半球之间的结合不同，以及2)新神经元的半球侧化与学习和记忆的行为和生理测量的关联程度。鸣禽为评估新神经元对半球特化的贡献提供了一个模型系统，因为鸣禽大脑中用于声音处理的区域在功能上是偏侧的，并且在成年后会不断地接受新神经元的涌入。在成年雄性斑胸草雀中，我们量化了尾侧足部（NCM）的新神经元，NCM是一个前脑区域，涉及个体同种动物复杂发声的识别和记忆。我们评估了NCM的歌曲学习并记录了对歌曲的神经反应。我们发现左侧标记的新神经元明显多于右侧标记的新神经元；此外，新神经元数量的不对称程度与歌曲学习的质量和对最近听过的歌曲的神经元记忆的强度相关。在实验中歌唱质量受损的鸟类中，新神经元的半球差异减弱。这些结果表明，新神经元可能有助于大脑半球之间的功能分配，这是复杂信号学习和处理的基础。
Many brain regions exhibit lateral differences in structure and function, and also incorporate new neurons in adulthood, thought to function in learning and in the formation of new memories. However, the contribution of new neurons to hemispheric differences in processing is unknown. The present study combines cellular, behavioral, and physiological methods to address whether 1) new neuron incorporation differs between the brain hemispheres, and 2) the degree to which hemispheric lateralization of new neurons correlates with behavioral and physiological measures of learning and memory. The songbird provides a model system for assessing the contribution of new neurons to hemispheric specialization because songbird brain areas for vocal processing are functionally lateralized and receive a continuous influx of new neurons in adulthood. In adult male zebra finches, we quantified new neurons in the caudomedial nidopallium (NCM), a forebrain area involved in discrimination and memory for the complex vocalizations of individual conspecifics. We assessed song learning and recorded neural responses to song in NCM. We found significantly more new neurons labeled in left than in right NCM; moreover, the degree of asymmetry in new neuron numbers was correlated with the quality of song learning and strength of neuronal memory for recently heard songs. In birds with experimentally impaired song quality, the hemispheric difference in new neurons was diminished. These results suggest that new neurons may contribute to an allocation of function between the hemispheres that underlies the learning and processing of complex signals.
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影响因子：
9.2
作者：
Güntürkün, O;Diekamp, B;Skiba, M
通讯作者：
Skiba, M
影响因子：
3.7
作者：
Gil-Mohapel J;Brocardo PS;Choquette W;Gothard R;Simpson JM;Christie BR
通讯作者：
Christie BR
DOI：
10.1126/science.1230531
发表时间：
2013-06-14
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bishop DV
通讯作者：
Bishop DV
影响因子：
4.5
作者：
Alary, Mathieu;Delcroix, Nicolas;Dollfus, Sonia
通讯作者：
Dollfus, Sonia
DOI：
10.1073/pnas.1302581110
发表时间：
2013-09-03
影响因子：
11.1
作者：
Gotts, Stephen J.;Jo, Hang Joon;Martin, Alex
通讯作者：
Martin, Alex