Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease.
Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease.
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DOI：
10.1002/mds.26759
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发表时间：
2016-11
影响因子：
8.6
通讯作者：
Kuehn, Andrea A.
中科院分区：
文献类型：
--
作者：
Neumann, Wolf-Julian;Degen, Katharina;Schneider, Gerd-Helge;Bruecke, Christof;Huebl, Julius;Brown, Peter;Kuehn, Andrea A.
丘脑底核 (STN) 的 β 带振荡被认为是帕金森病 (PD) 患者的病理生理学特征。本研究的目的是调查 STN 振荡活动与 PD 症状严重程度之间的潜在关联。记录了 63 名处于多巴胺能关闭状态的 PD 患者的丘脑底局部场电位。对 5 至 95 Hz 频率范围的功率谱进行了分析，并与关闭状态下的个体 UPDRS-III 运动评分相关。所有患者的 UPDRS-III 总分与 8 至 35 Hz 活动之间存在相关性 (ρ = 0.44，P <.0001)。当关联每个频率仓时，从 10 到 15 Hz 的狭窄范围对于相关性仍然很重要（错误发现率校正 P <.05）。我们的结果显示局部 STN 8 至 35 Hz 功率与 PD 损伤之间存在相关性，进一步支持底丘脑振荡活动作为 PD 潜在生物标志物的作用。
Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson’s disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in the STN and symptom severity in PD. Subthalamic local field potentials were recorded from 63 PD patients in a dopaminergic OFF state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and correlated with individual UPDRS-III motor scores in the OFF state. A correlation between total UPDRS-III scores and 8 to 35 Hz activity was revealed across all patients (ρ = 0.44, P <.0001). When correlating each frequency bin, a narrow range from 10 to 15 Hz remained significant for the correlation (false discovery rate corrected P <.05). Our results show a correlation between local STN 8 to 35 Hz power and impairment in PD, further supporting the role of subthalamic oscillatory activity as a potential biomarker for PD.
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晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
DOI：
10.1111/ner.12348
发表时间：
2016-01
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Neumann WJ;Staub F;Horn A;Schanda J;Mueller J;Schneider GH;Brown P;Kühn AA
通讯作者：
Kühn AA
影响因子：
3.4
作者：
Kühn, AA;Kupsch, A;Brown, P
通讯作者：
Brown, P
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
158.5
作者：
Krack, P;Batir, A;Pollak, P
通讯作者：
Pollak, P