New polyphenols from a deep sea Spiromastix sp. Fungus, and their antibacterial activities.
New polyphenols from a deep sea Spiromastix sp. Fungus, and their antibacterial activities.
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DOI：
10.3390/md13042526
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发表时间：
2015-04-22
期刊：
影响因子：
5.4
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Niu S;Liu D;Proksch P;Shao Z;Lin W
从一种深海真菌Spiromastix sp.MCCC3A00308的发酵液中分离得到11个新的多酚化合物，即spiromastolsA-K（1-11）。通过大量的NMR数据和质谱分析以及化学转化确定了它们的结构。其结构分为二苯醚、二苯醚和异香豆素衍生物，而正丙基在天然产物中很少发现。化合物1-3对一组细菌菌株表现出有效的抑制作用，包括水疱黄单胞菌、流泪假单胞菌、根癌农杆菌、青枯雷尔氏菌、苏云金芽孢杆菌、金黄色葡萄球菌和枯草芽孢杆菌，最小抑制浓度（MIC）值范围为0.25至4 μg/mL。的结构-活性关系进行了讨论，而多氯类似物1-3被认为是一个有前途的结构模型，为进一步开发的抗菌剂。
Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents.
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