Adherence to a healthy lifestyle in relation to colorectal cancer incidence and all-cause mortality after endoscopic polypectomy: A prospective study in three U.S. cohorts.
Adherence to a healthy lifestyle in relation to colorectal cancer incidence and all-cause mortality after endoscopic polypectomy: A prospective study in three U.S. cohorts.
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坚持健康的生活方式与内镜息肉切除术后结直肠癌发病率和全因死亡率的关系：一项美国三个队列的前瞻性研究
DOI：
10.1002/ijc.34176
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发表时间：
2022-11-01
影响因子：
6.4
通讯作者：
Song, Mingyang
中科院分区：
文献类型：
--
作者：
Wang, Liang;Knudsen, Markus D.;Lo, Chun-Han;Wang, Kai;He, Mingming;Polychronidis, Georgios;Hang, Dong;He, Xiaosheng;Zhong, Rong;Wu, Kana;Chan, Andrew T.;Ogino, Shuji;Giovannucci, Edward L.;Song, Mingyang
内镜下息肉切除术后保持健康的生活方式是否仍能降低结直肠癌（CRC）的发病率和死亡率，目前尚不清楚。在这项研究中，我们根据身体质量指数、吸烟、体育活动、饮酒和饮食（范围0-5）定义了健康生活方式评分。我们使用Cox比例风险回归来估计健康生活方式评分和个人生活方式因素与结直肠癌发病率和全因死亡率之间的风险比（hr）。在中位随访10年的24668名接受内镜息肉切除术的参与者中，我们记录了161例结直肠癌病例和4857例全因死亡。内镜息肉切除术后较高的健康生活方式评分与较低的结直肠癌风险和全因死亡率相关。与健康生活方式因素为0-1的个体相比，健康生活方式因素为2、3和4-5的个体CRC风险HR分别为0.86[95%置信区间（CI） 0.60-1.24]、0.73 （95% CI, 0.47-1.14）和0.52 (95% CI, 0.27-1.01) （p趋势=0.03）。全因死亡率相应的HR （95% CI）分别为0.83 （95% CI, 0.76-0.90）、0.63 （95% CI, 0.56 - 0.70）和0.56 (95% CI, 0.48-0.65) （p趋势<0.0001）。在息肉切除术前后的联合分析中，无论息肉切除术前的暴露程度如何，健康的息肉切除术后生活方式的患者CRC发病率较低，而在两个时期都有健康生活方式的患者死亡率低于任何一个时期都有不健康生活方式的患者。总之，息肉切除术后坚持健康的生活方式可能对预防结直肠癌和降低全因死亡率有显著的好处。
It remains unknown whether maintenance of a healthy lifestyle after endoscopic polypectomy could still confer benefit for colorectal cancer (CRC) incidence and mortality. In this study, we defined a healthy lifestyle score based on body mass index, smoking, physical activity, alcohol consumption, and diet (range, 0–5). We used Cox proportional hazards regression to estimate the hazard ratios (HRs) for the associations of healthy lifestyle score and individual lifestyle factors with CRC incidence and all-cause mortality. During a median of 10 years of follow-up of 24668 participants who underwent endoscopic polypectomy, we documented 161 CRC cases and 4857 all-cause deaths. A higher healthy lifestyle score after endoscopic polypectomy was associated with lower risk of CRC and all-cause mortality. Compared to individuals with 0–1 healthy lifestyle factors, those with 2, 3, and 4–5 healthy lifestyle factors had a HR for CRC risk of 0.86 [95% confidence interval (CI), 0.60–1.24], 0.73 (95% CI, 0.47–1.14), and 0.52 (95% CI, 0.27–1.01), respectively (Ptrend=0.03). The corresponding HR (95% CI) for all-cause mortality was 0.83 (95% CI, 0.76–0.90), 0.63 (95% CI, 0.56–0.70), and 0.56 (95% CI, 0.48–0.65), respectively (Ptrend<0.0001). In the joint analysis of pre- and post-polypectomy periods, patients with a healthy post-polypectomy lifestyle had a lower incidence of CRC regardless of their pre-polypectomy exposure, whereas those with a healthy lifestyle in both periods had a lower mortality than those with an unhealthy lifestyle in either period. In conclusion, adherence to a healthy lifestyle after polypectomy may confer significant benefit for CRC prevention and reduction in all-cause mortality.
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影响因子：
2.3
作者：
Makarem, Nour;Lin, Yong;Bandera, Elisa V.;Jacques, Paul F.;Parekh, Niyati
通讯作者：
Parekh, Niyati
结直肠癌危险因素与锯齿状息肉和传统腺瘤风险之间的关联。
影响因子：
29.4
作者：
He X;Wu K;Ogino S;Giovannucci EL;Chan AT;Song M
通讯作者：
Song M
DOI：
10.1136/bmj.c5504
发表时间：
2010-10-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Kirkegaard H;Johnsen NF;Christensen J;Frederiksen K;Overvad K;Tjønneland A
通讯作者：
Tjønneland A
DOI：
10.1007/s10552-015-0619-z
发表时间：
2015-09
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Erdrich J;Zhang X;Giovannucci E;Willett W
通讯作者：
Willett W
影响因子：
9.3
作者：
Hassan, Cesare;Quintero, Enrique;Lieberman, David
通讯作者：
Lieberman, David