Concordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991-2008).
Concordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991-2008).
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DOI：
10.1007/s10552-014-0509-9
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发表时间：
2015-02
影响因子：
2.3
通讯作者：
Parekh, Niyati
中科院分区：
文献类型：
--
作者：
Makarem, Nour;Lin, Yong;Bandera, Elisa V.;Jacques, Paul F.;Parekh, Niyati
关键词：
这项前瞻性队列研究评估了符合WCRF/AICR癌症预防指南的健康行为与肥胖相关癌症风险之间的关联，因为估计三分之一的癌症是可以预防的。研究样本由来自Frauetan Offspring队列的成年人组成（n = 2，983）。从1991年到2008年，共发现了480例医生诊断的肥胖相关癌症。1991年收集的饮食数据，通过食物频率问卷、人体测量和自我报告的身体活动来测量，用于构建基于身体肥胖、身体活动、促进体重增加的食物、植物性食物、动物性食物、酒精和食物保存、加工和准备的7个组成部分的评分。多变量考克斯回归模型用于估计计算的评分、其组成部分和与肥胖相关的癌症风险相关的子组成部分之间的关联。在调整年龄、性别、吸烟、能量和既往疾病后，总体评分与肥胖相关癌症风险无关（HR 0.94，95% CI 0.86-1.02）。当单独评估评分成分时，酒精评分每增加一个单位，肥胖相关癌症的风险降低29%（HR 0.71，95%CI 0.51-0.99），乳腺癌、前列腺癌和结直肠癌的风险降低49- 71%。在食用淀粉类蔬菜的参与者中，非淀粉类植物性食物（水果、蔬菜和豆类）的子成分评分每增加一个单位，结直肠癌风险降低66%（HR 0.44，95%CI 0.22-0.88）。在这一人群中，较低的酒精摄入量和符合癌症预防指南的植物性饮食与肥胖相关癌症的风险降低有关。
This prospective cohort study evaluates associations between healthful behaviors consistent with WCRF/AICR cancer prevention guidelines and obesity-related cancer risk, as a third of cancers are estimated to be preventable. The study sample consisted of adults from the Framingham Offspring cohort (n = 2,983). From 1991 to 2008, 480 incident doctor-diagnosed obesity-related cancers were identified. Data on diet, measured by a food frequency questionnaire, anthropometric measures, and self-reported physical activity, collected in 1991 was used to construct a 7-component score based on recommendations for body fatness, physical activity, foods that promote weight gain, plant foods, animal foods, alcohol, and food preservation, processing, and preparation. Multivariable Cox regression models were used to estimate associations between the computed score, its components, and subcomponents in relation to obesity-related cancer risk. The overall score was not associated with obesity-related cancer risk after adjusting for age, sex, smoking, energy, and preexisting conditions (HR 0.94, 95 % CI 0.86–1.02). When score components were evaluated separately, for every unit increment in the alcohol score, there was 29 % lower risk of obesity-related cancers (HR 0.71, 95 % CI 0.51–0.99) and 49–71 % reduced risk of breast, prostate, and colorectal cancers. Every unit increment in the subcomponent score for non-starchy plant foods (fruits, vegetables, and legumes) among participants who consume starchy vegetables was associated with 66 % reduced risk of colorectal cancer (HR 0.44, 95 % CI 0.22–0.88). Lower alcohol consumption and a plant-based diet consistent with the cancer prevention guidelines were associated with reduced risk of obesity-related cancers in this population.
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影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
7.1
作者：
Romaguera, Dora;Vergnaud, Anne-Claire;Norat, Teresa
通讯作者：
Norat, Teresa
影响因子：
--
作者：
KANNEL, WB;SORLIE, P
通讯作者：
SORLIE, P
DOI：
10.1158/1940-6207.capr-13-0258
发表时间：
2014-01
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Thomson CA;McCullough ML;Wertheim BC;Chlebowski RT;Martinez ME;Stefanick ML;Rohan TE;Manson JE;Tindle HA;Ockene J;Vitolins MZ;Wactawski-Wende J;Sarto GE;Lane DS;Neuhouser ML
通讯作者：
Neuhouser ML
DOI：
10.1158/1055-9965.epi-13-0210
发表时间：
2013-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hastert TA;Beresford SA;Patterson RE;Kristal AR;White E
通讯作者：
White E