Reliability of P3 Event-Related Potential During Working Memory Across the Spectrum of Cognitive Aging.
Reliability of P3 Event-Related Potential During Working Memory Across the Spectrum of Cognitive Aging.
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DOI：
10.3389/fnagi.2020.566391
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发表时间：
2020
影响因子：
4.8
通讯作者：
Gustafson K
中科院分区：
文献类型：
--
作者：
Devos H;Burns JM;Liao K;Ahmadnezhad P;Mahnken JD;Brooks WM;Gustafson K
事件相关电位（ERP）在追踪与正常和病理性认知老化相关的不同电生理过程中提供了无与伦比的时间分辨率。在具有广泛认知能力的老年人中，ERP的稳定性尚未建立。在这项重测信度研究中，39名老年人（年龄74.10（5.4）岁; 23例（59%）女性;蒙特利尔认知评估（莫卡）评分在3 - 30之间的15例非β-淀粉样蛋白升高，16例β-淀粉样蛋白升高，8例认知受损）在基线和2周随访时完成了具有三个难度水平的工作记忆（n-back）测试。主要目的是评价总样本（n = 39）中两次访视的ERP对总平均任务效应的稳定性。次要目的是评估年龄、组（非β-淀粉样蛋白升高; β-淀粉样蛋白升高，认知受损）、认知状态（莫卡）和任务难度对ERP可靠性的影响。在预定的通道中测量P3峰振幅和潜伏期。我们的主要结果变量Fz处的P3峰值振幅在0-back（组内相关系数（ICC），95%置信区间= 0.82（0.67-0.90））和1-back（ICC = 0.87（0.76-0.93））中显示出极好的可靠性，然而，在2-back（ICC = 0.53（0.09-0.75））中仅显示出中等可靠性。P3峰潜伏期的可靠性显著较低，ICC范围在2-back的0.17和0-back的0.54之间。广义线性混合模型显示，年龄，组，或任务难度的P3振幅和潜伏期的Fz的稳定性没有混杂效应。相比之下，莫卡评分往往与Fz的P3振幅呈负相关（p = 0.07）。我们得出结论，P3峰振幅，并在较小程度上P3峰潜伏期，提供了一个稳定的措施，在老年人的电生理过程。
Event-related potentials (ERPs) offer unparalleled temporal resolution in tracing distinct electrophysiological processes related to normal and pathological cognitive aging. The stability of ERPs in older individuals with a vast range of cognitive ability has not been established. In this test-retest reliability study, 39 older individuals (age 74.10 (5.4) years; 23 (59%) women; 15 non β-amyloid elevated, 16 β-amyloid elevated, 8 cognitively impaired) with scores on the Montreal Cognitive Assessment (MOCA) ranging between 3 and 30 completed a working memory (n-back) test with three levels of difficulty at baseline and 2-week follow-up. The main aim was to evaluate stability of the ERP on grand averaged task effects for both visits in the total sample (n = 39). Secondary aims were to evaluate the effect of age, group (non β-amyloid elevated; β-amyloid elevated, cognitively impaired), cognitive status (MOCA), and task difficulty on ERP reliability. P3 peak amplitude and latency were measured in predetermined channels. P3 peak amplitude at Fz, our main outcome variable, showed excellent reliability in 0-back (intraclass correlation coefficient (ICC), 95% confidence interval = 0.82 (0.67–0.90) and 1-back (ICC = 0.87 (0.76–0.93), however, only fair reliability in 2-back (ICC = 0.53 (0.09–0.75). Reliability of P3 peak latencies was substantially lower, with ICCs ranging between 0.17 for 2-back and 0.54 for 0-back. Generalized linear mixed models showed no confounding effect of age, group, or task difficulty on stability of P3 amplitude and latency of Fz. By contrast, MOCA scores tended to negatively correlate with P3 amplitude of Fz (p = 0.07). We conclude that P3 peak amplitude, and to lesser extent P3 peak latency, provide a stable measure of electrophysiological processes in older individuals.
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DOI：
10.1016/j.pnpbp.2012.08.009
发表时间：
2013-01-10
影响因子：
5.6
作者：
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